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Determination of serum lactate and potassium and blood gas values in dogs with anemia who received transfusions of red blood cells with different storage periods

Grant number: 12/03020-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2012
Effective date (End): October 31, 2013
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Aline Magalhães Ambrósio
Grantee:Renata Ramos Rodrigues
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The storage of red blood cells (CH) can result in biochemical changes in blood gas and blood transfusion which can induce the occurrence of clinical and laboratory variables in patients receiving. It is known that from 7 days of storage, can be observed increased levels of potassium and lactate and decreased pH in whole blood of dogs. However, it is unclear whether similar changes also occur during storage of the canine and CH is no difference between the clinical and laboratory dogs receiving CH with different storage periods. Therefore, this prospective, randomized clinical study aims to compare the concentrations of lactate and potassium and blood gas values in dogs with anemia receiving CH stored for different periods and to investigate if these values correlate with those found in CH transfused. To do so, will be evaluated 21 adult dogs that will randomly CH contained in bags with CPDA-1 stored at a temperature of 4-6 ° C for up to 7 days (group I, n = 7), CH stored for 8 to 14 days (group II, n = 7) or CH stored for 15 to 21 days. Will be evaluated and the concentrations of potassium lactate and blood gas values of the dogs immediately before transfusion, after the transfusion, and 24 hours after transfusion of CH. These same factors will also be measured in the CH immediately before its administration. The data will be submitted for analysis of variance for repeated measures followed by Tukey's test and t-Student. The degree of significance for statistical analysis will be p<0,05.(AU)

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