Advanced search
Start date
Betweenand

Profile and prevalence of myositis-specific autoantibodies and myositis-associated in the Brazilian population with dermatomyositis / polymyositis.

Grant number: 12/03399-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2012
Effective date (End): April 30, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Samuel Katsuyuki Shinjo
Grantee:Marcela Gran Pina Cruellas
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of chronic autoimmune disease, systemic, associated with high morbidity and functional disability. Considering the clinical and histopathological features, the MII can be classified into polymyositis (PM), dermatomyositis (DM), juvenile dermatomyositis (JDM), inclusion body myositis (IBM), myositis associated with malignancy and myositis associated with other collagen diseases. The etiology of both DM and PM remains unknown, but is believed to be multifactorial involving genetic, immunological and environmental. Thus, the presence of lymphocytic infiltrates in muscle tissue in most patients with IIM, as well as myositis-specific autoantibodies and myositis-associated circulation and deposits in the endothelial cells of blood vessels found in muscle biopsies, strongly suggest the involvement of processes in the pathogenesis of IIM immune compromising muscle function. On the other hand, the description of these autoantibodies has allowed a better characterization of the diagnosis of IIM, and extrapolate their possible associations with clinical, immunogenetic, evolution, and prognosis. However, to date, no reports of evaluation of the profile and the distribution of these autoantibodies in the Brazilian population with DM / PM and its clinical association. Thus, it would be of interest to establish a comparison of the reactivity pattern of our patients with that already described in other populations.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARLOS DE SOUZA, FERNANDO HENRIQUE; PINA CRUELLAS, MARCELA GRAN; LEVY-NETO, MAURICIO; SHINJO, SAMUEL KATSUYUKI. Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 53, n. 4, p. 352-357, Ago. 2013. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.