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Prevalence of HPV in oral fluid and its risk factors in HIV-1-infected men.

Grant number: 11/16094-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): August 31, 2013
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Jorge Simão do Rosário Casseb
Grantee:Karen Eliane de Oliveira Gaester
Host Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Introduction: Human Papillomavirus (HPV) belongs to the Papillomaviridae family and is considered a sexually transmitted infection, highly disseminated, with about 50% of sexually active adults infected. In HIV-infected individuals, oral HPV infection is more frequent, with more aggressive manifestations, prevalence and high rate of resistance, as well as a greater number of relapses treatment against HPV. Objectives: To determine the prevalence of HPV in oral fluid in men infected with HIV-1, HPV types and to correlate the presence of HPV and the risk factors associated with oral transmission. Material and method: 300 samples will be collected oral wash male patients, from the Secondary Immunodeficiencies Clinic. The oral lavage samples will be subjected to DNA extraction, amplification by conventional PCR, using primers and PGMY09 PGMY11, and HPV types will be determined by test, Restriction Fragment Length Polymorphism (RFLP). Our preliminary data showed a high presence of HPV in oral fluid (~ 30%). This study will determine the prevalence and risk factors associated with the presence of HPV in HIV-infected men, it will be important in the prevention and possible use of prophylactic vaccines.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GAESTER, KAREN; FONSECA, LUIZ A. M.; LUIZ, OLINDA; ASSONE, TATIANE; FONTES, ADRIELE SOUZA; COSTA, FERNANDO; DUARTE, ALBERTO J. S.; CASSEB, JORGE. Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors. SCIENTIFIC REPORTS, v. 4, . (10/07076-4, 11/16094-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GAESTER, Karen Eliane de Oliveira. Human Papillomavirus infection in the oral fluid of HIV-infected men: Prevalence and relation with risk factors. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Medicina Tropical de São Paulo (IMT) São Paulo.

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