Synthesis of Co@Au (superparamagnetics) and CdSe@Zn (quantum dots) core@shell nanostructures for applications as antineoplasia agents

• Grant number: 12/02093-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2012
• End date: March 25, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Laudemir Carlos Varanda
• Grantee: João Batista Souza Junior
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 07/07919-9 - Colloidal magnetic nanocrystals: synthesis of self-assembled and macromolecules-functionalised nanospheres, nanowires, and nanorods for advanced magnetic recording, biotechnological, and biomedical applications, AP.JP
• Associated scholarship(s): 14/10736-7 - Synthesis of CdSe-CdS dot-in-rod core-shell nanostructures, BE.EP.DR

Abstract

Recently, magnetic and quantum dot nanoparticles are intensively studied as new materials for cancer diagnostic and therapy due to their unique properties, mainly such as magnetic, optical, electric and photoluminescent. In the case of nanomaterials, these properties are also size-dependent or size-tunable, which justified the strongest interest in this materials science scale range. For biomedical applications, in a new area called as nanomedicine, superparamagnetic behavior at room temperature and colloidal stability, as well as surface biocompatible and low toxicity, are necessary for magnetic materials. In this way, there are several advantages of core/shell nanostructure uses, for example Co/Au, for cancer therapy. Advantages consist basically to connect the high saturation magnetization (~ 1422 emu.cm-3) and superparamagnetic behavior of the Co core with size up to 8 nm, and the gold coating that confer large surface functionalization possibilities, low toxicity and high colloidal and chemical stabilities. Similarly, core/shell quantum dots of CdSe/ZnS present enhanced photoluminescent properties for application in cancer image and photodynamic therapy due to their efficient electronic structure which confer superior photostability and longer photoluminescent lifetime. However, applications of these nanomaterials in biomedicine require rigorous size and shape control, and narrow size distribution to adjust their properties. In addition, materials surface must have non-toxicity and selectivity by cancer cells membranes that can be obtained by using specific, synthetic or natural, biocompatible macromolecules. Consequently, the goal of this project is developing synthetic methods for obtaining monodisperse core/shell nanostructures of Co/Au and CdSe/ZnS with size, shape, and chemical composition control. After that, colloidal stability and specificity by cancer cells will be investigated by appropriate surface functionalization of these systems using biocompatible polymers and biologically active molecules.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALBERS, REBECCA F.; BINI, RAFAEL A.; SOUZA, JR., JOAO B.; MACHADO, DERIK T.; VARANDA, LAUDEMIR C.. A general one-pot synthetic strategy to reduced graphene oxide (rGO) and rGO-nanoparticle hybrid materials. Carbon, v. 143, p. 73-84, MAR 2019. (13/18542-4, 12/02093-3, 13/01284-2)

SECCO DE SOUZA, CAIO GUILHERME; SOUZA, JR., JOAO BATISTA; BECK, JR., WATSON; VARANDA, LAUDEMIR CARLOS. Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor. Journal of Nanomaterials, 2017. (12/02093-3, 13/01284-2, 07/07919-9)

THIAGO MAZZU-NASCIMENTO; FABIANA CRISTINA DONOFRIO; BEATRIZ CUTILAK BIANCHI; REGIANE DE FÁTIMA TRAVENSOLO; JOÃO BATISTA SOUZA JUNIOR; DANIEL ANGELI MORAES; GIORGIO GIANINI MORBIOLI; THIAGO PINOTTI SEGATO; LAUDEMIR CARLOS VARANDA; EMANUEL CARRILHO. Paper-Based Microfluidics Immunoassay for Detection of Canine Distemper Virus. Brazilian Archives of Biology and Technology, v. 60, 2018-01-08. (11/13997-8, 12/02093-3)

MASCARENHAS, BRUNO C.; VARANDA, LAUDEMIR C.. Catalytic hydrogenation of organic dyes by Ag nanoparticles on reduced graphene oxide. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 103, p. 124-135, NOV 25 2021. (13/01284-2, 13/18542-4, 12/02093-3)

MORAES, DANIEL A.; SOUZA JUNIOR, JOAO B.; FERREIRA, FABIO F.; MOGILI, NAGA VISHNU V.; VARANDA, LAUDEMIR C.. Gold nanowire growth through stacking fault mechanism by oleylamine-mediated synthesis. NANOSCALE, v. 12, n. 25, p. 13316-13329, JUL 7 2020. (12/02093-3, 13/01284-2)

SOUZA, JR., JOAO B.; VARANDA, LAUDEMIR C.. Magneto-plasmonic Au-Coated Co nanoparticles synthesized via hot-injection method. Nanotechnology, v. 29, n. 6, FEB 9 2018. (10/04208-7, 12/02093-3, 13/01284-2, 07/07919-9)

SECCO DE SOUZA, CAIO GUILHERME; SOUZA, JOAO BATISTA, JR.; BECK, WATSON, JR.; VARANDA, LAUDEMIR CARLOS. Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor. Journal of Nanomaterials, v. 2017, p. 9-pg., 2017-01-01. (13/01284-2, 12/02093-3, 07/07919-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOUZA JUNIOR, João Batista. Syntheses of Core/Shell Nanostructures of Magnetoplasmonic Co/Au and CdSe/ZnS quantum dots. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.