Investigation of unregulated pathways involving NR4A family proteins in myelodysplastic syndromes and acute leukemia

• Grant number: 12/00111-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2012
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Sara Teresinha Olalla Saad
• Grantee: Flávia Adolfo Corrocher
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Myelodysplastic syndrome (MDS) is caused by a heterogeneous group of disorders in hematopoietic stem cells characterized by dysplastic changes in the bone marrow and ineffective hematopoiesis. The consequences of this impaired hematopoiesis are peripheral blood cytopenias, that may involve all three segments of the blood: erythrocytes, leukocytes and platelets. Previous results of microarray identified several genes whose expression was modulated in CD34+ and stromal cells of patients with SMDs and also RNAs non-coding (ncRNAs) that possibly make up signaling networks that control, integrate and regulate mechanisms transcriptional, post transcriptional and epigenetic. The NR4A subfamily of nuclear receptors are transcription factors involved in various cellular functions in which exonic and intronic regions showed hyperexpression in microarray analysis performed on CD34+ cells in patients with MDS. There are only two studies in the literature relating these proteins with AML (acute myeloid leukemia) and MDS and the results are still contradictory. Therefore, the aim of this study is to investigate the role of coding and noncoding transcripts of these proteins in bone marrow disease through overexpression and functional studies of the same.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORROCHER, FLAVIA ADOLFO; DE PAIVA, LUCIANA BUENO; SANTOS DUARTE, ADRIANA SILVA; FERRO, KARLA PRISCILA; SILVEIRA, LEONARDO DOS REIS; DE LIMA, TANES IAMAMURA; OLALLA SAAD, SARA TERESINHA; LAZARINI, MARIANA. Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells. Leukemia & Lymphoma, v. 59, n. 6, p. 1501-1504, 2018. (11/51959-0, 12/00111-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CORROCHER, Flávia Adolfo. Investigation of dysregulated pathways involving lncRNA and NR4A1 protein in myelodysplasia and acute leukemia. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.