NATURAL RUBBER-BASED MICROFLUIDIC DEVICE (LAB-ON-A-SHIP)

• Grant number: 11/23362-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2012
• End date: February 28, 2015
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Aldo Eloizo Job
• Grantee: Flávio Camargo Cabrera
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

This PHD project intends to undertake research in the manufacturing of natural rubber micro-devices for analysis in real time, called lab-on-a-ship, prepared from Hevea brasiliensis latex (clone RRIM 600), by casting technique and applied for evaluation of fluids, injected by using a peristaltic pump, ranging from the matrix preparation to the construction of optical sensors inside the optical window and finally the optimization of the device in order to generate the emissions data through micro-circuits connected to the internal sensors. The choice of materials was based on the mechanical properties, high flexibility, which facilitates the sustainability of the device, also biocompatible properties of natural rubber membranes, currently widely tested in biomedicine, favoring the application of devices such as biological sensors.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CABRERA, FLAVIO C.; DE SOUZA, JOAO C. P.; JOB, ALDO E.; CRESPILHO, FRANK N.. Natural-rubber-based flexible microfluidic device. RSC ADVANCES, v. 4, n. 67, p. 35467-35475, 2014. (11/23362-0, 13/04663-4, 13/14262-7)

CABRERA, FLAVIO C.; DOGNANI, GUILHERME; FAITA, FABRICIO L.; DOS SANTOS, RENIVALDO J.; AGOSTINI, DEUBER L. S.; BECHTOLD, IVAN H.; CRESPILHO, FRANK N.; JOB, ALDO E.. Vulcanization, centrifugation, water-washing, and polymeric covering processes to optimize natural rubber membranes applied to microfluidic devices. Journal of Materials Science, v. 51, n. 6, p. 3003-3012, MAR 2016. (11/23362-0, 13/04663-4, 13/14262-7)

CABRERA, FLAVIO C.; MELO, ANTONIO F. A. A.; DE SOUZA, JOAO C. P.; JOB, ALDO E.; CRESPILHO, FRANK N.. A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles. LAB ON A CHIP, v. 15, n. 8, p. 1835-1841, 2015. (11/23362-0, 13/04663-4, 13/14262-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CABRERA, Flávio Camargo. Dispositivo microfluídico de borracha natural (LAB-ON-A-CHIP). 2015. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências. Bauru Bauru.