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Evaluation of the biocompatibility, kinases and microRNAs involved on the adhesion phenomenons of osteoblastos to modified titanium surfaces.

Grant number: 12/03633-1
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Elcio Marcantonio Junior
Grantee:Ana Rosa Lopes Pereira Ribeiro
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Titanium and its alloys have been widely used in biomedical applications, namely in dental and orthopedic implants.Nanotechnology applying surface functionalization techniques has been recently used in dental implants surfaces. In this project surface modification techniques will be used on titanium, the biomaterial commonly used in dental implants, in order to fulfil, simultaneously, the following requirements: induce an increased osseoconductivity, avoid microbial colonization, superior corrosion and wear performance (tribocorrosion). Nanostructured surfaces will be produced on commercial pure Ti after several functionalization techniques. The main aim of this project is to understand the signalling transduction mechanisms associated with adhesion of osteoblasts to the diferente functionalized titanium surfaces. Also kinases and micro RNAs will be evaluated. This project is expected to decisively contribute to the fundamental knowledge on the effect of surface properties on the biological interaction with materials. This will help the multifunctional surface that could be applied on denta choosing l implants, contributing for the increase of the lifetime of dental implants and patient healthcare and confort.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, A. R.; OLIVEIRA, F.; BOLDRINI, L. C.; LEITE, P. E.; FALAGAN-LOTSCH, P.; LINHARES, A. B. R.; ZAMBUZZI, W. F.; FRAGNEAUD, B.; CAMPOS, A. P. C.; GOUVEA, C. P.; et al. Micro-arc oxidation as a tool to develop multifunctional calcium-rich surfaces for dental implant applications. Materials Science & Engineering C-Materials for Biological Applications, v. 54, p. 196-206, . (12/03633-1)

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