Physical-chemical and in vitro functional characterization of bioactive sunscreens

• Grant number: 12/13621-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): September 01, 2012
• Effective date (End): March 31, 2013
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: André Rolim Baby
• Grantee: Mariana Moreira Guimarães
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The tendency for sunscreens development with reduced concentration of chemical filters is of great relevance, due to the risk of adverse effects caused by them. Despite the availability of different filters and natural substances, the market lacks photoprotective formulations containing flavonoids. The skin, property compatible with the desired action of sunscreens, does not absorb Rutin, a flavonoid compound. The research aims to prepare physical-chemical and in vitro functional characterization of bioactive sunscreens. Polymer emulsion will contain a concentration of rutin (0,10% w/w), associated or not with organic ultraviolet B (UVB) filters in their maximum and minimum concentrations, according to international regulations. The formulations will be submitted to Preliminary Assessment of Stability, by means of centrifuge test and thermal stress. The in vitro determination of the sun protection factor (SPF) will occur in specific equipment for this purpose, the diffuse reflectance spectrophotometry with integrating sphere. The results will be submitted to statistical analysis by analysis of variance (ANOVA) followed by Tukey test, in order to determine differences between and within groups.(AU)