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Transcriptional profile comparisons between infected and uninfected target tissues related to bovine respiratory disease

Grant number: 12/01502-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Start date: July 01, 2012
End date: March 31, 2013
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Luciana Correia de Almeida Regitano
Grantee:Polyana Cristine Tizioto
Supervisor: Jeremy Francis Taylor
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Institution abroad: University of Missouri, Columbia (UM), United States  
Associated to the scholarship:10/06515-4 - Prospection and validation of SNPs in candidate genes for meat tenderness in reference families of Nellore breed, BP.DR

Abstract

Bovine respiratory disease is a major problem for the U.S. beef and dairy industry. Selection of BRD-resistant cattle is ultimately the most sustainable approach to reducing the incidence of disease, as resistant animals have improved animal welfare, decreased use of therapeutic antibiotics, have superior production efficiency, require less handling, and are ultimately more profitable. Recent developments in molecular genetics and genotyping platforms offer a unique opportunity to identify a large number of the loci and genomic rearrangements associated with the spectrum of bovine respiratory disease (BRD) pathogens. The research objective of this proposal is to identify genetic loci associated with BRD using RNA sequencing (RNA-Seq) to obtain information about genome-wide gene expression profiles within the sampled tissues. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TIZIOTO, POLYANA C.; KIM, JAEWOO; SEABURY, CHRISTOPHER M.; SCHNABEL, ROBERT D.; GERSHWIN, LAUREL J.; VAN EENENNAAM, ALISON L.; TOAFF-ROSENSTEIN, RACHEL; NEIBERGS, HOLLY L.; TAYLOR, JEREMY F.; COORDINATE, BOVINE RESP DIS COMPLEX. Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome. PLoS One, v. 10, n. 6, . (12/01502-7)
TIZIOTO, POLYANA C.; TAYLOR, JEREMY F.; DECKER, JARED E.; GROMBONI, CAIO F.; MUDADU, MAURICIO A.; SCHNABEL, ROBERT D.; COUTINHO, LUIZ L.; MOURAO, GERSON B.; OLIVEIRA, PRISCILA S. N.; SOUZA, MARCELA M.; et al. Detection of quantitative trait loci for mineral content of Nelore longissimus dorsi muscle. GENETICS SELECTION EVOLUTION, v. 47, . (10/06515-4, 12/01502-7)