Study of the anti-oxidative and anti-inflammatory capacity of in natura and germinated bean (Phaseolus vulgaris and Vigna unguiculata) hydrolyzed flour

• Grant number: 12/19034-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: January 01, 2014
• End date: April 30, 2014
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Technology
• Principal Investigator: Yoon Kil Chang
• Grantee: Thaís de Souza Rocha
• Supervisor: Elvira de Mejia
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: University of Illinois at Urbana-Champaign, United States
• Associated to the scholarship: 12/04796-1 - Study of the anti-oxidative and anti-inflammatory capacity of in natura and germinated bean (Phaseolus vulgaris and Vigna unguiculata) hydrolyzed flour., BP.PD

Abstract

The interest of using COX-2 (cyclooxygenase), PGE2 (prostaglandin E2), TNF-± (tumor necrosis factor), and NO (nitric oxide) inhibitors to treat inflammatory diseases is increasing. Due to significant production and consumption of beans in Brazil, it is important to study the presence of these inhibitors in Brazilian varieties of beans. The objective of this project is to verify the effect of different concentrations of bioactives peptides obtained from enzymatic hydrolysis of in natura and germinated common bean and cowpea flour on the proliferation and modular properties of the oxidative response (NO, COX-2, iNOS), and the inflammatory response (TNF-± e PGE2)) using a murine macrophages model. This verification should be realized at University of Illinois at Urbana-Champaign under supervision of Dr. Elvira G. de Mejia, who is studying for over 15 years the bioactives compounds of food with benefic properties to human health. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROCHA, THAIS DE SOUZA; REAL HERNANDEZ, LUIS MANUEL; MOJICA, LUIS; JOHNSON, MICHELLE H.; CHANG, YOON KIL; DE MEJIA, ELVIRA GONZALEZ. Germination of Phaseolus vulgaris and alcalase hydrolysis of its proteins produced bioactive peptides capable of improving markers related to type-2 diabetes in vitro. Food Research International, v. 76, n. 1, SI, p. 150-159, OCT 2015. (12/19034-0)

ROCHA, THAIS DE SOUZA; HERNANDEZ, LUIS MANUEL REAL; CHANG, YOON KIL; DE MEJIA, ELVIRA GONZALEZ. Impact of germination and enzymatic hydrolysis of cowpea bean (Vigna unguiculata) on the generation of peptides capable of inhibiting dipeptidyl peptidase IV. Food Research International, v. 64, p. 799-809, OCT 2014. (12/19034-0)

ROCHA, THAIS DE SOUZA; REAL HERNANDEZ, LUIS MANUEL; MOJICA, LUIS; JOHNSON, MICHELLE H.; CHANG, YOON KIL; DE MEJIA, ELVIRA GONZALEZ. Germination of Phaseolus vulgaris and alcalase hydrolysis of its proteins produced bioactive peptides capable of improving markers related to type-2 diabetes in vitro. Food Research International, v. 76, p. 10-pg., 2015-10-01. (12/19034-0)