Evaluation of the persistence of acute thrombus in the late phase of DVT.

• Grant number: 12/14082-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2012
• End date: October 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Joyce Maria Annichino-Bizzacchi
• Grantee: Bruna de Moraes Mazetto Fonseca
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Deep vein thrombosis (DVT) is a major public health problem. It is estimated that the annual incidence of DVT is 67 per 100,000 individuals in the general population.The treatment of DVT is based on the use of anticoagulants and intended to prevent complications of the disease. The complications of DVT are thrombus progression and embolization, which can cause death of the patient. Late complications are post-thrombotic syndrome (PTS), chronic pulmonary hypertension and recurrent DVT.Ultrasound Doppler (US) has become the principal tool for the diagnosis and monitoring of disease progression. The image analysis of the US, however, is a subjective and operator-dependent method, particularly in the evaluation of chronic venous obstruction.Thrombus characterization is important because it may grade embolization risk embolization and may dictate changes in treatment with time. The analysis of the damaged venous wall may have provide information about disease complications. Several studies have used computer-assisted US image analyses to obtain a more objective and quantitative assessment of the echogenicity of atherosclerotic plaques in the carotid and peripheral arteries. Thus, the use of a similar analysis in the context of DVT could contribute to a more accurate evaluation of residual thrombus and could potentially rise as a new prognostic marker for DVT and the risk of recurrence.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MAZETTO, BRUNA M.; ORSI, FERNANDA L. A.; SILVEIRA, SANDRA A. F.; BITTAR, LUIS FERNANDO; FLORES-NASCIMENTO, MARIANE C.; ZAPPONI, KIARA C. S.; COLELLA, MARINA P.; DE PAULA, ERICH V.; ANNICHINO-BIZZACCHI, JOYCE M.. Severe postthrombotic syndrome is associated with characteristic sonographic pattern of the residual thrombosis. BLOOD COAGULATION & FIBRINOLYSIS, v. 27, n. 6, p. 673-678, SEP 2016. (12/14082-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FONSECA, Bruna de Moraes Mazetto. Evaluation of presence and echogenicity of the residual thrombus in the late phase of venous thrombosis and its association with post-thrombotic syndrome and disease recurrence. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.