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Histologic and histomorphometric evaluation of the association between bioactive glass and lyophilized bovine bone in the treatment of critical bone defects created in rats calvaria

Grant number: 12/05150-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2013
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Rosemary Adriana Chierici Marcantonio
Grantee:José Rodolfo Spin
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Biomaterials are used during an indeterminate period of time as a whole or as a part of a biological system for treatment, ampliation or replacement of any tissues, organs or body functions. The objective of this study will be to make a histological and histomorphometric evaluation of bioglass, lyophilized bovine bone, and a combination of lyophilized bovine bone with bioglass use (1:1) in critical bone defects created in rats calvaria. To this, critical bone defects of 8 mm in diameter will be surgically created in the calvaria of 24 rats (Rattus norvegicus, Albinus variation Holtzman) and filled with blood clot (negative control), bioglass, lyophilized bovine bone, and the association between bovine bone lyophilized and bioglass, in a 1:1 ratio, and covered with a collagen membrane, totaling six animals, divided into two experimental periods (15 and 60 days), for each biomaterial. The histological evaluation will be based on the description of the morphology of newly formed tissue in the defect region. The histomorphometric evaluation will be based on the quantification of the percentage of newly formed bone, soft tissue, and biomaterial remaining in the defect area treated.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JOSÉ RODOLFO SPIN; GUILHERME JOSÉ PIMENTEL LOPES DE OLIVEIRA; RUBENS SPIN-NETO; JULIANA RICO PIRES; HEWERSON SANTOS TAVARES; FRANK YKEDA; ROSEMARY ADRIANA CHIÉRICI MARCANTONIO. Avaliação histomorfométrica da associação entre biovidro e osso bovino liofilizado no tratamento de defeitos ósseos críticos criados em calvárias de ratos. Estudo piloto. Rev. odontol. UNESP, v. 44, n. 1, p. 37-43, . (12/05150-8)

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