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Central and cardiovascular effects resulting from association between exercise and testosterone administration on ethanol drinking in rats

Grant number: 12/14723-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2012
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Cleopatra da Silva Planeta
Grantee:Sheila Antonagi Engi
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):14/23231-0 - Elucidating the role of ribosomal translation machinery in alcohol abuse disorders, BE.EP.DR


Drug abuse is considered a major public health problem in the world. The use of anabolic-androgenic steroids (AAS)and ethanol has increased in Brazil in the last few years. Studies indicate that the combination between physic exercise, AAS and ethanol intake has consequences to the organism. Although the relevance of the topic, a comprehensive review of the literature revealed the presence of few studies investigating the consequences of the simultaneous combination of this factors in complex systems of the body, such as central nervous system and the cardiovascular system. There is evidence that the practice of exercise and AAS can modify the effects on ethanol intake. Thus, this project aims to investigate in rats: 1) the impact of combined exercise and AAS administration on ethanol intake; 2) the toxic cardiovascular effects resulting from exercise, AAS administration and ethanol intake; 3) molecular changes in dopaminergic and opioidergic pathways involved in the association between exercise, AAS and ethanol intake.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ENGI, SHEILA A.; PLANETA, CLEOPATRA S.; CRESTANI, CARLOS C. Effect of Voluntary Ethanol Consumption Combined with Testosterone Treatment on Cardiovascular Function in Rats: Influence of Exercise Training. PLoS One, v. 11, n. 1 JAN 13 2016. Web of Science Citations: 4.

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