Effects of physical training and testosterone on ethanol - induced changes in the ...
| Grant number: | 12/14723-1 |
| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | November 01, 2012 |
| Effective date (End): | May 31, 2016 |
| Field of knowledge: | Biological Sciences - Pharmacology - Neuropsychopharmacology |
| Principal Investigator: | Cleopatra da Silva Planeta |
| Grantee: | Sheila Antonagi Engi |
| Home Institution: | Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil |
| Associated scholarship(s): | 14/23231-0 - Elucidating the role of ribosomal translation machinery in alcohol abuse disorders, BE.EP.DR |
Abstract Drug abuse is considered a major public health problem in the world. The use of anabolic-androgenic steroids (AAS)and ethanol has increased in Brazil in the last few years. Studies indicate that the combination between physic exercise, AAS and ethanol intake has consequences to the organism. Although the relevance of the topic, a comprehensive review of the literature revealed the presence of few studies investigating the consequences of the simultaneous combination of this factors in complex systems of the body, such as central nervous system and the cardiovascular system. There is evidence that the practice of exercise and AAS can modify the effects on ethanol intake. Thus, this project aims to investigate in rats: 1) the impact of combined exercise and AAS administration on ethanol intake; 2) the toxic cardiovascular effects resulting from exercise, AAS administration and ethanol intake; 3) molecular changes in dopaminergic and opioidergic pathways involved in the association between exercise, AAS and ethanol intake. | |