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Effect of treatment of artificial caries with resin infiltrant followed by new acid challenged

Grant number: 12/13157-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Linda Wang
Grantee:Larissa Vasconcellos Nunes
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


Caries is a multifactor infectious disease that causes demineralization of hard dental tissues due to the acids produced by bacterial metabolism. Its first clinical sign correspond to a white spot at dental enamel. Current preventive scenario looks for strategies of treatment to early lesions in order to avoid its progression and consequent need of invasive treatment. An alternative treatment to early lesions recently launched in market is the resinous infiltrant. This is a resinous agent with high penetration ability that infiltrates dental tissue and fill the porosities of the demineralized enamel, hampering its progression. Laboratorial investigations that analyze this product have been performed using mainly an artificial caries model. As other models are commonly used in Cariology investigations, they could respond differently to the infiltrant action. Other limitation from the other studies is the lack of a new acid challenge to assess the resistance after treatment. This study aims to evaluate by microhardness, the effect of infiltrant Icon® on different artificial caries lesions and its resistance after new acid challenge. So, artificial caries lesions will be produced in 120 bovine enamel specimens under three different protocols ( MC gel, MHDP solution and DES-RE cycle). The specimens will be treated with Icon® and followed submitted to a new acid challenge DES-RE. Surface and longitudinal microhardness assessment will be evaluated in three times: after demineralization, after treatment with infiltrant and after new acid challenge. The data will be collected and statistically analyzed according to the verified distribution. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARVALHO DE ALMENDRA FREITAS, MARIA CRISTINA; NUNES, LARISSA VASCONCELLOS; COMAR, LIVIA PICCHI; RIOS, DANIELA; MAGALHAES, ANA CAROLINA; HONORIO, HEITOR MARQUES; WANG, LINDA. In vitro effect of a resin infiltrant on different artificial caries-like enamel lesions. ARCHIVES OF ORAL BIOLOGY, v. 95, p. 118-124, NOV 2018. Web of Science Citations: 3.

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