Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model in cirrhotic patients

• Grant number: 12/15677-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: January 01, 2013
• End date: January 31, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Dan Linetzky Waitzberg
• Grantee: Giliane Belarmino
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Malnutrition due to liver disease is common, however, their detection is difficult. The parameters used for nutritional assessment in clinical practice have limited use in this patient population. From this perspective, this study proposes to develop predictive equations for body composition for electrical bioimpedance (BIA) in cirrhotic patients. Besides being a fast and risk free, the BIA offers the additional advantage of low cost compared to other methods that assess body composition (BC). Will be selected patients male with liver cirrhosis (n = 112) of the Liver Transplant Clinic of the Hospital of the Clinicas, Faculty of Medicine, University of São Paulo. After signing an informed consent, the patient sample will be divided into four groups: cirrhotic patients with ascites without edema, cirrhotic patients with ascites with edema, cirrhotic patients without ascites with edema and cirrhotic patients without ascites without edema (control group) and BC will be estimated by bioelectrical impedance analysis and by reference method (multicomponent model). The data obtained by both methods are statistically treated to obtain specific BIA prediction equations for the evaluation of cirrhotic patients. This pioneering study is of great clinical importance because malnutrition is a relevant factor in the prognosis of liver disease and there is not efficient method in clinical practice to properly assess the body composition in this population. Such knowledge, in turn, can serve as a new tool for nutritional assistance in treating this disease. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELARMINO, GILIANE; HORIE, LILIAN MIKA; SALA, PRISCILA CAMPOS; TORRINHAS, RAQUEL S.; HEYMSFIELD, STEVEN B.; WAITZBERG, DAN L.. Body adiposity index performance in estimating body fat in a sample of severely obese Brazilian patients. NUTRITION JOURNAL, v. 14, DEC 30 2015. (12/15677-3, 11/09612-3, 11/13243-3)

BELARMINO, GILIANE; GONZALEZ, MARIA CRISTINA; TORRINHAS, RAQUEL S.; SALA, PRISCILA; ANDRAUS, WELLINGTON; CARNEIRO D'ALBUQUERQUE, LUIZ AUGUSTO; PEREIRA, ROSA MARIA R.; CAPARBO, VALERIA F.; RAVACCI, GRAZIELA R.; DAMIANI, LUCAS; et al. Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis. WORLD JOURNAL OF HEPATOLOGY, v. 9, n. 7, p. 401-408, MAR 8 2017. (12/15677-3, 11/13243-3)

BELARMINO, G.; SINGER, P.; GONZALEZ, M. C.; MACHADO, N. M.; CARDINELLI, C. S.; BARCELOS, S.; ANDRAUS, W.; D'ALBUQUERQUE, L. A. C.; DAMIANI, L.; COSTA, A. C.; et al. Prognostic value of energy expenditure and respiratory quotient measuring in patients with liver cirrhosis. Clinical Nutrition, v. 38, n. 4, p. 1899-1904, AUG 2019. (11/13243-3, 12/15677-3)

BELARMINO, GILIANE; GONZALEZ, MARIA CRISTINA; SALA, PRISCILA; TORRINHAS, RAQUEL SUSANA; ANDRAUS, WELLINGTON; CARNEIRO D'ALBUQUERQUE, LUIZ AUGUSTO; PEREIRA, ROSA MARIA R.; CAPARBO, VALERIA F.; FERRIOLI, EDUARDO; PFRIMER, KARINA; et al. Diagnosing Sarcopenia in Male Patients With Cirrhosis by Dual-Energy X-Ray Absorptiometry Estimates of Appendicular Skeletal Muscle Mass. Journal of Parenteral and Enteral Nutrition, v. 42, n. 1, p. 24-36, JAN 2018. (12/15677-3, 11/13243-3)