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Optimization of biosensors based on the interaction between reduced graphene oxide and biomolecules

Grant number: 12/22755-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Susana Inés Córdoba de Torresi
Grantee:Rafael Neri Prystaj Colombo
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/53199-3 - Molecular recognition and energy storage: fundamental studies concerning geometry, size and synthesis effects on the optimization of the chemical properties of electroactive materials, AP.TEM


Biosensors constitute an intrinsic element in daily life and present a promissory future, being a central facet in its use for the most different functions, from clinical laboratory diagnosis to in vivo monitoring systems. With the nano-science development, increasing attention relying on carbon nanotubes (CNT) usage was verified for bio-recognition of several compounds. Recently, the ascension of the research based on reduced graphene oxide (RGO) depicts it as an excellent intermediate electrode-substrate material, with satisfactory electrochemical responses forthcoming mainly both from its electron availability for conduction on delocalized pi bonds and from the presence of functional groups in the structure of the oxide. The present project offers a pursuit on the optimization of the electrochemical biosensors based on the direct electronic interaction between sp2 hybridized carbon layers and biomolecules, probing the relation between immobilized RGO and biologic material so that a small quantity of RGO does not suitably recover the electrode's surface, whereas an excess of RGO adhered may promote multi-layering, thus reducing the electrochemical performance of the carbon nanomaterial. Therefore, the improvement of the sensor does comprehend several steps and is expected to produce a set of parameters for better process resourcefulness, such as the number of immobilized carbon monolayers, optimization on reduction method, and biomolecule adsorption, factors that are commonly used arbitrarily on researches from this segment.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GORICALES, VINICIUS R.; COLOMBO, RAFAEL N. P.; MINADEO, MARCO A. O. S.; MATSUBARA, ELAINE Y.; MAURICIO ROSOLEN, J.; CORDOBA DE TORRESI, SUSANA I.. Three-dimensional graphene/carbon nanotubes hybrid composites for exploring interaction between glucose oxidase and carbon based electrodes. Journal of Electroanalytical Chemistry, v. 775, p. 235-242, . (11/15159-0, 11/08581-7, 12/22755-0)
COLOMBO, RAFAEL N. P.; PETRI, DENISE F. S.; CORDOBA DE TORRESI, SUSANA I.; GONCALES, VINICIUS R.. Porous Polymeric Templates on ITO Prepared by Breath Figure Method for Gold Electrodeposition. Electrochimica Acta, v. 158, p. 187-195, . (09/53199-3, 12/22755-0, 11/15159-0)

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