Development of label-free biosensors based on graphene

• Grant number: 21/12458-8
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Effective date (Start): March 01, 2022
• Effective date (End): February 28, 2023
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Osvaldo Novais de Oliveira Junior
• Grantee: Gustavo Gonçalves Dalkiranis Pereira
• Supervisor: Arben Merkoci
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Research place: Catalan Institute of Nanoscience and Nanotechnology (ICN2), Spain
• Associated to the scholarship: 19/26375-7 - Study of the thermoelectric properties of NDI-2Tz polymer and its application on a microthermoelectric generator, BP.PD

Abstract

The academic and industrial community have devoted many efforts to diagnose diseases quickly, easily and with a low cost. Within this framework, the biosensors have been extensively studied, since those are devices able to detect biological structure by changing their chemical and/or physical properties. In this Project, label-free biosensors based on graphene to detect cancer biomarkers will be fabricated. A technique using DVD-burner laser recently developed by Nanobioelectronics and Biosensors Group will be used to produce reduced-graphene oxide thin films on different flexible substrates. The solutions to detect biomarkers of pancreatic cancer (CA19-9) and prostate cancer (PCA3) will be prepared and deposited on devices with interdigitated electrodes and electrochemical sensor, thus producing label-free biosensors. The devices produced by this Project will be integrated with the thermoelectric generator that is under development in the post-doctorate project number 2019/26375-7, in order to fabricate an autonomous system. In addition, this Project will establish a collaboration between the Group of Polymers "Prof. Bernhard Gross" and the Nanobioelectronics and Biosensors Group, which will produce devices that fulfill the goals of the thematic project number 2018/22214-6, being one of the expected contributions of this Project. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DALKIRANIS, GUSTAVO G.; BOCCHI, JOAO H. C.; OLIVEIRA JR, OSVALDO N.; FARIA, GREGORIO C.. Geometry Optimization for Miniaturized Thermoelectric Generators. ACS OMEGA, v. 8, n. 10, p. 7-pg., 2023-03-01. (21/12458-8, 18/22214-6, 19/26375-7)

DALKIRANIS, GUSTAVO GONCALVES; BASILIO, FERNANDO COSTA; NOBUYASU, ROBERTO S.; CURCINO DA SILVA, SILESIA DE FATIMA; NOGUEIRA, SANDRA LUCIA DIAS; THEREZIO, ERALCI MOREIRA; SEREIN-SPIRAU, FRANCOISE; SILVA, RAIGNA A.; MARLETTA, ALEXANDRE. Photoluminescent ellipsometric circular dichroism. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 293, p. 8-pg., 2023-02-07. (21/12458-8, 19/26375-7)