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Development of field effect nanobiosensors based on graphene for detection of biomarkers

Grant number: 14/01663-6
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): May 05, 2014
Effective date (End): May 04, 2015
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Valtencir Zucolotto
Grantee:Nirton Cristi Silva Vieira
Supervisor abroad: Paulo Freitas
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Local de pesquisa : International Iberian Nanotechnology Laboratory (INL), Portugal  
Associated to the scholarship:11/20110-0 - Field effect-based immunosensors to detect myocardial infarction markers, BP.PD

Abstract

Biosensors which utilize nanomaterials or nanobiosensors as active layer have different or improved properties as compared with conventional biosensors. Nowadays , graphene - an allotropic form of carbon with 2-dimensional structure - have shown promise for the development of nanobiosensors, especially those based on effect-effect transistors or FET due to structural uniformity and high electron mobility displayed by this material. In this sense , this project is proposed the development and application of new nanobiosensors field effect of graphene based technique manufactured by CVD ( chemical vapor deposition from the vapor phase) . The CVD technique provides an excellent reproducibility , which is desirable in sensors, mainly for large-scale manufacturing . After the improvement of the manufacturing process, nanobiosensors will be applied to the detection of specific proteins , which act as biomarkers of disease . The high affinity between biological systems , coupled with the sensitivity of graphene FET transistors are promising for development of integrated detection paving the way for new technologies in diagnostic platforms . In this way, this project is proposed the development and application of new field-effect nanobiosensors based on graphene manufactured by CVD ( chemical vapor deposition) technique. CVD technique provides an excellent reproducibility, which is desirable in sensors, mainly for large-scale manufacturing . After the improvement of the manufacturing process, the nanobiosensors will be applied to the detection of specific proteins that act as disease biomarkers. The high affinity between biological systems along with the sensitivity of graphene FET transistors are promising for development of integrated detection platforms, opening the way for new technologies in diagnostic. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, N. C. S.; BORME, J.; MACHADO, JR., G.; CERQUEIRA, F.; FREITAS, P. P.; ZUCOLOTTO, V.; PERES, N. M. R.; ALPUIM, P. Graphene field-effect transistor array with integrated electrolytic gates scaled to 200 mm. JOURNAL OF PHYSICS-CONDENSED MATTER, v. 28, n. 8 MAR 2 2016. Web of Science Citations: 12.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.