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Field effect-based immunosensors to detect myocardial infarction markers

Grant number: 11/20110-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2012
Effective date (End): January 04, 2016
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Valtencir Zucolotto
Grantee:Nirton Cristi Silva Vieira
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):14/01663-6 - Development of field effect nanobiosensors based on graphene for detection of biomarkers, BE.EP.PD


Research on accurate methods of diagnosis for cardiovascular diseases (CVDs), especially in the diagnosis of Myocardial infarction (MI) has intensified both in the clinic, and in academia, since MI is the major cause of CVD deaths. Aiming to contribute to the development of integrated platforms for rapid diagnosis, this project proposes the fabrication of an immunosensor device able to detect troponin I, a candidate biomarker for myocardial infarct. The idea is to apply a field effect transistor (FET) as signal transducer for specific detection of troponin I. The field effect based Immunosensors have several advantages including high sensitivity and possibility of production in large scale. We believe that the idea of combining field effect devices with high-affinity antibody-antigen is promising for the fabrication of a immunological biosensor capable of conferring an accurate diagnosis of MI in an low cost manner. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Sensor detects dengue before the first symptoms appear 
Researchers create biosensor to detect pesticide 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, NIRTON C. S.; AVANSI, JR., WALDIR; FIGUEIREDO, ALESSANDRA; MASTELARO, VALMOR R.; ZUCOLOTTO, VALTENCIR. Potentiometric detection of chemical species by spin-assisted assembly of vanadium pentoxide nanorods. SENSORS AND ACTUATORS B-CHEMICAL, v. 229, p. 461-465, JUN 28 2016. Web of Science Citations: 3.
FIGUEIREDO, ALESSANDRA; VIEIRA, NIRTON C. S.; DOS SANTOS, JULIANA F.; JANEGITZ, BRUNO C.; AOKI, SERGIO M.; JUNIOR, PAULO P.; LOVATO, RODRIGO L.; NOGUEIRA, MAURICIO L.; ZUCOLOTTO, VALTENCIR; GUIMARAES, FRANCISCO E. G. Electrical Detection of Dengue Biomarker Using Egg Yolk Immunoglobulin as the Biological Recognition Element. SCIENTIFIC REPORTS, v. 5, JAN 19 2015. Web of Science Citations: 23.
VIEIRA, NIRTON C. S.; FIGUEIREDO, ALESSANDRA; DOS SANTOS, JULIANA F.; AOKI, SEGIO M.; GUIMARAES, FRANCISCO E. G.; ZUCOLOTTO, VALTENCIR. Label-free electrical recognition of a dengue virus protein using the SEGFET simplified measurement system. ANALYTICAL METHODS, v. 6, n. 22, p. 8882-8885, 2014. Web of Science Citations: 4.

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Filed patent(s) as a result of this research project

MICRODISPOSITIVOS DETECTORES DO VÍRUS DA DENGUE; PROCESSO DE PRODUÇÃO DE MICRODISPOSITIVOS DETECTORES DO VÍRUS DA DENGUE; KIT CONTENDO O MESMO E MÉTODO DE IDENTIFICAÇÃO DA DENGUE BR1020130243191 - Dnapta Biotecnologia Ltda ; Universidade de São Paulo (USP) . Francisco Eduardo G. Guimaraes; Valtencir Zucolotto; Alessandra Figueiredo; Nirton Cristi Silva Vieira; Haroldo Arakaki; Rodrigo Lemos Lovato; Sergio Moraes Aoki; Paulo Peitl Junior - September 2013, 23