Effect of supplementation with DHEA in the heart of rats with hypertension induced by castration and high fat diet

• Grant number: 12/14183-7
• Support type: Scholarships in Brazil - Master
• Effective date (Start): January 01, 2013
• Effective date (End): February 28, 2014
• Field of knowledge: Biological Sciences - Physiology
• Principal researcher: Carla Roberta de Oliveira Carvalho
• Grantee: Caio Jordão Teixeira
• Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Deprivation sex hormones, natural or induced, contributes to the appearance of several metabolic and endocrine disorders such as insulin resistance, glucose intolerance and diabetes, and cardiovascular diseases, due in part to the protective effect of estrogens. Dehydroepiandrosterone (DHEA), most abundant steroid in humans, produce primarily by the adrenal cortex, is converted to androgens and estrogens in peripheral tissues. In postmenopausal women in the synthesis of estrogens and androgens are made locally in peripheral tissues by tissue-specific steroidogenic enzymes through a process intrácrino, with the adrenal precursor steroids DHEA, DHEA-S and androstenedione. The use of DHEA as food supplement, both in humans and in experimental models, was related to reduced obesity, insulin resistance and the risk of cardiovascular disease. Furthermore, recently published that supplementation with DHEA to rats hypertensive due to ovariectomy plays a protective role in aortic rings assessed for response to vasoconstrictors and vasodilatoadores with anti-inflammatory and antioxidant (Camporez et al., 2011). The objective of the current master's project is to evaluate the effect of DHEA supplementation on the morphology of ventricular myocytes and cardiac expression of inflammatory cytokines and receptors for insulin and IGF-1 in hearts of obese and hypertensive rats due to castration and high-fat diet . Parameters will be evaluated zoomorphic, glycemic control, expression of proteins involved in pathways of insulin and IGF-1 and inflammatory cytokines and morphometric parameters in cardiac muscle tissue of the left ventricle (LV). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEIXEIRA, CAIO JORDAO; VERAS, KATHERINE; DE OLIVEIRA CARVALHO, CARLA ROBERTA. Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period. JOURNAL OF MOLECULAR MEDICINE-JMM, NOV 2019. Web of Science Citations: 0.

TEIXEIRA, CAIO JORDAO; RIBEIRO, LUCIENE MARIA; VERAS, KATHERINE; DA CUNHA ARAUJO, LAYANNE CABRAL; CURI, RUI; DE OLIVEIRA CARVALHO, CARLA ROBERTA. Dehydroepiandrosterone supplementation is not beneficial in the late postmenopausal period in diet-induced obese rats. Life Sciences, v. 202, p. 110-116, JUN 1 2018. Web of Science Citations: 2.