Effects of the exposure to particulate matter on the development of acute lung injury induced by LPS.

• Grant number: 12/23334-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2013
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Luiz Fernando Ferraz da Silva
• Grantee: Natália de Souza Xavier Costa
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 08/57717-6 - National Institute for Integrated Analysis of Environmental Risk, AP.TEM

Abstract

Studies have shown that there is an association with air pollution and increased indices of mortality and morbidity in urban population. These effects are more clearly seen in susceptible individuals that have previous cardio-respiratory diseases and elderly people. The particulate matter is a mixture of suspended solid and liquid droplets and is the most frequently associated pollutant to the health adverse effects of air pollution (e.g. systemic and pulmonary inflammation, decreased lung function and aggravation of asthma and bronchitis. The objective of this study is to examine the impact of urban air pollution on the progression of a pre existent lung inflammation and to evaluate if the progression and response of the lung to inflammation is different in those individuals previously exposed to urban polluted air. The experimental model will use LPS delivered by nebulization to induce Lung injury. Lungs, brochoalveolar lavage and blood serum will be obtained and inflammatory profile will be evaluated by different techniques (immunohistochemistry and ELISA). Lungs morphofunctional evaluation will be conducted using stereological methods.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA XAVIER COSTA, NATALIA; RIBEIRO JUNIOR, GABRIEL; DOS SANTOS ALEMANY, ADAIR APARECIDA; BELOTTI, LUCIANO; FROTA CAVALCANTE, MARCELA; RIBEIRO, SUSAN; MATERA VERAS, MARIANA; KALLAS, ESPER GEORGES; SALDIVA, PAULO HILARIO NASCIMENTO; DOLHNIKOFF, MARISA; et al. LPS Response Is Impaired by Urban Fine Particulate Matter. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 7, p. 18-pg., 2022-04-01. (12/23334-9, 08/57717-6)

XAVIER COSTA, NATALIA DE SOUZA; RIBEIRO JUNIOR, GABRIEL; DOS SANTOS ALEMANY, ADAIR APARECIDA; BELOTTI, LUCIANO; SCHALCH, ALEXANDRE SANTOS; CAVALCANTE, MARCELA FROTA; RIBEIRO, SUSAN; VERAS, MARIANA MATERA; KALLAS, ESPER GEORGES; NASCIMENTO SALDIVA, PAULO HILARIO; et al. Air pollution impairs recovery and tissue remodeling in a murine model of acute lung injury. SCIENTIFIC REPORTS, v. 10, n. 1, p. 14-pg., 2020-09-17. (08/57717-6, 12/23334-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

COSTA, Natália de Souza Xavier. Effects of the exposure to atmospheric particulate matter on the development of LPS-induced acute lung injury (ALI). 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.