Computational model of rat hippocampus dentate gyrus for the study of effects of granular cells morphological alterations as a result of Status Epilepticus induced by pilocarpine.

• Grant number: 12/17057-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2013
• End date: December 31, 2013
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Antonio Carlos Roque da Silva Filho
• Grantee: Héctor Julián Tejada Herrera
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Dentate gyrus granule cells exhibit several changes as a result of Status Epilepticus induced by pilocarpine, including alterations in dendritic tree and in their axonal targets, the latter being denominated mossy fiber sprouting. Previous experimental and computationally works have shown that mossy fiber sprouting has a crucial role on hiperexcitability of dentate gyrus, however, the role of dendritic tree alterations is still unknown. The aim of the present project is to build a computational model of the dentate gyrus to study the possible effects of dendritic tree alterations on the network. In a second stage, the model will be used to evaluate the coupled effect of morphological alterations and changes in biophysical membrane properties, such as ion channel alterations. The goal is to use the computational model to make predictions on how different sources of variations (morphological and biophysical) interacting and affect the excitability of the circuit. Furthermore, the model will be made available in online repositories (e.g. NeuronDB: http://senselab.med.yale.edu/neurondb/) to allow other groups to extend our work.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEJADA, JULIAN; GARCIA-CAIRASCO, NORBERTO; ROQUE, ANTONIO C.. Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus. PLOS COMPUTATIONAL BIOLOGY, v. 10, n. 5, MAY 2014. (12/17057-2)

TEJADA, JULIAN; ROQUE, ANTONIO C.. Computational models of dentate gyrus with epilepsy-induced morphological alterations in granule cells. Epilepsy & Behavior, v. 38, n. SI, p. 63-70, SEP 2014. (12/17057-2)

TEJADA, JULIAN; GARCIA-CAIRASCO, NORBERTO; ROQUE, ANTONIO C.. Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus. PLOS COMPUTATIONAL BIOLOGY, v. 10, n. 5, p. 11-pg., 2014-05-01. (12/17057-2)

TEJADA, JULIAN; ROQUE, ANTONIO C.. Computational models of dentate gyrus with epilepsy-induced morphological alterations in granule cells. Epilepsy & Behavior, v. 38, p. 8-pg., 2014-09-01. (12/17057-2)