Insulin signaling pathway and HSR action in rodent longevity.

• Grant number: 12/24629-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2013
• End date: March 31, 2018
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Mario Jose Abdalla Saad
• Grantee: Kelly Lima Calisto da Silva
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
• Associated scholarship(s): 16/13788-3 - Mycoplasma Pathogenicity: Alternative Models and Diagnostics., BE.EP.PD

Abstract

Aging is an inherent process in all living beings. Cumulative damage leads to alterations in homeostasis and metabolic disorders. A variety of genes involved in cellular and molecular mechanisms of repair and defense have been analyzed for their association with human longevity. Changes in insulin / insulin growth factor 1 - (IIS signaling Insulin/IGF-1like) signaling pathway are known to affect a variety of functions involved in increased longevity and stress resistance. Mutations that decrease the signal transduction of IIS pathway increase the responsiveness stress types and longevity. The HSR is a mechanism that allows cells to respond to adverse environmental and metabolic conditions. This response is implicated in extending longevity and repair cellular damage. A recent study showed that increased longevity in C.elegans with IIS signaling pathway inactivating mutantions is mediated by the action of HSF-1 (Heat shock factors-1), heat shock factor that regulates the activation of HSR (Heat Shock Response). Taken together, these evidences indicate that IIS pathway affects longevity through HSF-1 regulators and that these regulators are a link between IIS signaling and extending longevity. However regulation of this pathway in aging in mammals has not been investigated yet. In this context, the aim of this study was to evaluate the modulation of insulin signaling pathway and HSR in young and senescent animals in different situations of insulin resistance.