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Effect of high fat diet on hepatocytes: impacts on ROS generation

Grant number: 13/03556-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2013
Effective date (End): December 31, 2015
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:Pâmela Aiako Hypólito Brito Kakimoto
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:10/51906-1 - Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism, AP.TEM
Associated scholarship(s):15/04232-9 - Effects of lipids on insulin signaling in hepatocytes: impacts on mitochondrial ROS and nitric oxide generation, BE.EP.IC


Lipid catabolism dysfunctions and consequent accumulation of these substrates in the liver are related to increase the generation of reactive oxygen species (ROS) and the development of metabolic diseases. Recently we described the participation of very long chain acyl-CoA dehydrogenases (VLCADs) on ROS generation by liver mitochondria of animals treated with high fat diet (Cardoso, under review). Those enzymes are members of flavoproteins family, acyl-CoA dehydrogenases, which catalyze the limiting step of beta-oxidation and enable electron transfer to electron transport chain. However, the mechanisms of regulation have not been totally completely elucidated. Our project aims to study the mechanisms of generation of ROS by VLCADs in animals treated with high fat diet.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAKIMOTO, PAMELA A.; KOWALTOWSKI, ALICIA J.. Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance. REDOX BIOLOGY, v. 8, p. 216-225, . (10/51906-1, 13/07937-8, 13/03556-0)

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