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Evaluation of the titanium tetrafluoride (TiF4) interaction with sound and demineralized human enamel in vitro

Grant number: 12/00662-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Ana Carolina Magalhães
Grantee:Jéssica Martins
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


This study aims to analyze (1) the presence of elements (SEM-EDS) on the surface of human enamel treated with fluoride varnishes and (2) the formation of CaF2 on the human enamel surface after the application of TiF4 and NaF varnishes in vitro. Human enamel samples (sound and previously demineralized in vitro) will be treated with different concentrations of TiF4 and NaF varnishes for subsequent analysis using SEM-EDS, in order to evaluate the surface qualitative and quantitatively (% elements). To evaluate the amount of CaF2 deposited on the human enamel surface (sound and previously demineralized in vitro) after treatment with TiF4 and NaF varnishes, basic biopsies (KOH-soluble F) will be performed. For the statistical analysis, the assumptions of equality of variances and normal distribution of errors will be checked for all the variables tested. Therefore, data will be tested using the most appropriate statistical test (parametric or non-parametric). The sample size will range from 5 to 10 and significance level for all tests will be set at 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COMAR, L. P.; SOUZA, B. M.; MARTINS, J.; SANTOS, M. G.; BUZALAF, M. A. R.; MAGALHAES, A. C. Response of carious enamel to TiF4 varnish treatment under diverse cariogenic activities in situ. Journal of Dentistry, v. 63, p. 81-84, AUG 2017. Web of Science Citations: 7.
COMAR, LIVIA P.; SOUZA, BEATRIZ M.; AL-AHJ, LUANA P.; MARTINS, JESSICA; GRIZZO, LARISSA T.; PIASENTIM, ISABELLE S.; RIOS, DANIELA; RABELO BUZALAF, MARILIA AFONSO; MAGALHAES, ANA CAROLINA. Mechanism of Action of TiF4 on Dental Enamel Surface: SEM/EDX, KOH-Soluble F, and X-Ray Diffraction Analysis. Caries Research, v. 51, n. 6, p. 554-567, 2017. Web of Science Citations: 5.

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