Production of polymeric scaffolds by rotary-jet-spinning technique with incorporated carbon nanotubes

• Grant number: 13/07696-0
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): June 01, 2013
• Effective date (End): May 31, 2014
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Anderson de Oliveira Lobo
• Grantee: Marco Antonio Vieira Macedo Grinet
• Home Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
• Associated research grant: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration, AP.JP

Abstract

This Project presents a new method for the fabrication of bioabsorbeable polymeric scaffolds containing superhydrophilic carbon nanotubes (MWCNT-O2) incorporated through the rotary-jet-spinning technique seeking the production of artificial nervous orientation conduits. Polylactic acid (PLA) will be used as a bioabsorbable polymeric matrix. The MWCNT-O2 will be produced with the Thermal vapor phase chemical deposition technique. Then, the MWCNT-O2 will be functionalized using hydrochloric acid and oxygen plasma to obtain superhydrophilicity. The MWCNT-O2 will be dispersed in various concentrations of mass/volume in a mixture of polar solvents seeking solubility and the consequent homogeneity for the production of the nanocomposites. Parameters will be evaluated for the production process of the nanofibers, such as: rotation speed, distance of the collector and superficial tension of the polymeric solution. The scaffolds produced will be morphologically and structurally characterized through: sweeping electron microscopy, energy dispersive x-ray, infrared spectroscopy and thermogravimetric analysis. As results, it is expected to be obtained a new nanobiomaterial that presents homogenous distribution of MWCNT-O2. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIQUEIRA, IDALIA A. W. B.; OLIVEIRA, CILIANA A. G. S.; ZANIN, HUDSON; GRINET, MARCO A. V. M.; GRANATO, ALESSANDRO E. C.; PORCIONATTO, MARIMELIA A.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O. Bioactivity behaviour of nano-hydroxyapatite/freestanding aligned carbon nanotube oxide composite. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 26, n. 2 FEB 2015. Web of Science Citations: 5.

GRINET, MARCO A. V. M.; ZANIN, HUDSON; CAMPOS GRANATA, ALESSANDRO EUSTAQUIO; PORCIONATTO, MARIMELIA; MARCIANO, FERNANDA ROBERTA; LOBO, ANDERSON OLIVEIRA. Fast preparation of free-standing nanohydroxyapatite-vertically aligned carbon nanotube scaffolds. JOURNAL OF MATERIALS CHEMISTRY B, v. 2, n. 9, p. 1196-1204, MAR 7 2014. Web of Science Citations: 18.