Action of bioactive glass-ceramic (Biosilicate) in the process of bone repair

• Grant number: 12/04449-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2013
• End date: March 31, 2015
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Claudia Muniz Renno
• Grantee: Hueliton Wilian Kido
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Bone healing is a highly complex regenerative process that includes the interaction of a series of biological events. These events are crucial for the restoration of the bone tissue integrity. During this process, there may be changes that culminate in the deficiency of regeneration and, consequently, the delay of the consolidation, or non-union bone. In such cases, it's necessary to use bone-replacement implants to favor bone regeneration. The Biosilicate® scaffolds have proven to be viable biomaterials for use as bone implants, because they have an appropriate structure for tissue growth and also a great osteogenic potential. However, it is not known their real influence in the mechanisms of action and biological interactions that underlie the process of bone repair. In this sense, molecular evidence would be of great value for an accurate understanding of this biological scenario, whereas this biomaterial induces cellular and molecular changes that manage bone formation. Within this context, this study aims to evaluate the effects of Biosilicate® scaffolds in the consolidation of tibial bone defects in rats, using histological analyzes, analysis of gene expression related to bone regeneration and analysis of inflammatory mediators levels during tissue repair. These informations enable a more precise understanding of the mechanisms by which this biomaterial interacts with biological system during the process of bone repair. Finally, these investigations may contribute to the development of further studies with the biomaterial in order to develop an effective and reliable treatment for fracture healing. (AU)