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Differencially expressed proteins indentification in differents tissues from epilepsy experimental models

Grant number: 13/09214-3
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2013
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Iscia Teresinha Lopes Cendes
Grantee:Amanda Morato Do Canto
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools, AP.TEM

Abstract

The epilepsies are chronic neurological diseases caused by changes in the brain functions that affect about 2% of the world population (Hauser et al., 1996; Borges et al., 2004). A common feature from all kind of epilepsy is the occurrence of seizures due to abnormal neuronal discharge that occurs in a transient, synchronic and disorganized way, taking to clinical manifestation resulting from the Central Nervous System affected area (Zielinski, 1988). The temporal lobe epilepsy (TLE) is the most frequent type of adults epilepsy, clinically characterized by a progressive development of epileptic seizures with focus on temporal lobe, being associated with hippocampus sclerosis (HE). The use of animals models for studies about human disorders is important for the understanding of the physiopathology mechanisms of those diseases. Particularly, the models that reproduce the human temporal lobe epilepsy in rodents present epileptogenicity similar to those finding in epileptics human tissues when it is studied ex vivo. For this, the proteomic has powerful tools that allow us to elucidate biological mechanisms and to find changed proteins in the whole organism, as a response to internal and external status, development changes, and others. Beyond that it allow us to describe the protein expression patterns (Krapfenbauer et al., 2003; Yang et al., 2005). Therefore, it is important analyze the proteins expression patterns from the hippocampus of animal models using proteomics techniques, as a complementary information to help us understand this pathogenesis. So, we propose to work with animal models, and use the proteomics to validate data obtained from the new generation sequencing, and to identify differentially expressed proteins.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CANTO, Amanda Morato Do. Identification of differentially expressed proteins in animal models of epilepsy. 2015. Master's Dissertation - Universidade Estadual de Campinas. Faculdade de Ciências Médicas.

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