Study of molecular mechanisms involved in the reduction of obese rodents treated with liraglutide

• Grant number: 13/10493-4
• Support type: Scholarships in Brazil - Master
• Effective date (Start): September 01, 2013
• Effective date (End): June 30, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Patrícia de Oliveira Prada
• Grantee: Giovanna Tase Ricardo
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The type 2 diabetes mellitus (T2DM) has become a serious and growing public health problem, affecting both developed and developing countries. Installation is associated with obesity and insulin resistance. Liraglutide represents a class of injectable drugs for the treatment of T2DM known as incretino-mimetic which exhibit similar effects to human incretin hormone called glucagon-like peptide-1 (GLP-1). In parallel to improved peripheral insulin sensitivity, treatment with liraglutide is associated with weight loss by increasing satiety. However, the molecular mechanism by which the liraglutide exerts this effect is not yet fully understood. The anorexigenic effect of insulin and leptin is well described. However, it was studied whether the treatment with liraglutide may change the action of these hormones and signaling in the central nervous system (CNS). Thus, this project will investigate the action and insulin signaling in the hypothalamus and amygdala as well as leptin in the hypothalamus of animals with obesity and diabetes treated with liraglutide. Evidence suggests that the control of food intake induced by GLP-1 is dependent on the vagus nerve. Therefore, the action and signaling of insulin and leptin will be investigated in the hypothalamus and amygdala of obese and diabetic animals treated with liraglutide who suffer vagotomy. Additionally, the effect of the drug on the induction mechanisms of insulin resistance in CNS such as ER stress, inflammatory pathway, activation of PTP1B, will be studied in the hypothalamus and amygdala.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RICARDO, Giovanna Tase. Effects of treatment with Liraglutide in signaling pathways of insulin and leptin in the hypothalamus of DIO mice. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas.