ASSOCIATION BETWEEN EPICARDIAL ADIPOSE TISSUE INFLAMMATION AND CORONARY ARTERY DISEASE: A CLINICOPATHOLOGICAL STUDY

• Grant number: 13/12290-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2013
• End date: September 30, 2015
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Claudia Kimie Suemoto
• Grantee: Daniela Souza Farias Itao
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Introduction: One of the main cause of morbidity and mortality in the world is coronary artery disease (CAD). Studies that investigate the pathophysiology of CAD are important to the prevention and treatment of this disease. The inflammation in epicardial adipose tissue (EAP) appears to be associated with CAD. However, the relation between the proximity of CAD and inflammation in EAP has not been elucidated in previous studies due to methodological limitations. Aim: To investigate the association between inflammation in EAP and coronary artery atherosclerosis in a clinicopathological study. Methods: This cross-sectional study will be performed at the Sao Paulo Autopsy Service. A sample of 78 cases will be collected. Coronary arteries (the main left coronary artery, circumflex, left anterior descending and right coronary) will be represented in the point of the highest obstruction. The samples will be divided in three groups: control, acute CAD, chronic CAD, according to obstruction degree and anatomopathologic classification of atherosclerosis. The sample of EAP near the coronary artery stenosis will be analyzed. Perirenal visceral adipose tissue and subcutaneous adipose tissue will be considered an external control to epicardial inflammation. The inflammatory cells (macrophages, lymphocytes B and T) will be quantified using immunochemistry. The quantity of inflammatory cells will be compared between three groups.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NISHIZAWA, ALINE; SUEMOTO, CLAUDIA K.; FARIAS-ITAO, DANIELA S.; CAMPOS, FERNANDA M.; SILVA, KAREN C. S.; BITTENCOURT, MARCIO S.; GRINBERG, LEA T.; LEITE, RENATA E. P.; FERRETTI-REBUSTINI, RENATA E. L.; FARFEL, JOSE M.; et al. Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study. PLoS One, v. 12, n. 10, OCT 16 2017. (13/12290-3)

NISHIZAWA, ALINE; SUEMOTO, CLAUDIA KIMIE; FARIAS, DANIELA SOUZA; CAMPOS, FERNANDA MARINHO; SOUZA DA SILVA, KAREN CRISTINA; CUELHO, ANDERSON; PARAIZO LEITE, RENATA ELAINE; DE LUCENA FERRETTI-REBUSTINI, RENATA ELOAH; GRINBERG, LEA TENENHOLZ; FARFEL, JOSE MARCELO; et al. Association between adiposity and systemic atherosclerosis: a protocol of a cross-sectional autopsy study. OPEN HEART, v. 3, n. 2, AUG 2016. (13/12290-3, 12/25337-5)

CICILIATI, ALINE MARIA M.; ADRIAZOLA, IZABELA ONO; SOUZA FARIAS-ITAO, DANIELA; PASQUALUCCI, CARLOS AUGUSTO; LEITE, RENATA ELAINE PARAIZO; NITRINI, RICARDO; GRINBERG, LEA T.; JACOB-FILHO, WILSON; SUEMOTO, CLAUDIA KIMIE. Severe Dementia Predicts Weight Loss by the Time of Death. FRONTIERS IN NEUROLOGY, v. 12, MAY 14 2021. (13/12290-3, 06/55318-1, 17/24066-1)

NISHIZAWA, ALINE; CUELHO, ANDERSON; DE FARIAS-ITAO, DANIELA S.; CAMPOS, FERNANDA M.; LEITE, RENATA E. P.; FERRETTI-REBUSTINI, RENATA E. L.; GRINBERG, LEA T.; NITRINI, RICARDO; JACOB-FILHO, WILSON; PASQUALUCCI, CARLOS A.; et al. Direct Measurements of Abdominal Visceral Fat and Cognitive Impairment in Late Life: Findings From an Autopsy Study. FRONTIERS IN AGING NEUROSCIENCE, v. 11, MAY 7 2019. (12/25337-5, 13/12290-3, 17/11313-0)

FARIAS-ITAO, DANIELA SOUZA; PASQUALUCCI, CARLOS AUGUSTO; NISHIZAWA, ALINE; DA SILVA, LUIZ FERNANDO FERRAZ; CAMPOS, FERNANDA MARINHO; BITTENCOURT, MARCIO SOMMER; DA SILVA, KAREN CRISTINA SOUZA; LEITE, RENATA ELAINE PARAIZO; GRINBERG, LEA TENENHOLZ; FERRETTI-REBUSTINI, RENATA ELOAH DE LUCENA; et al. B Lymphocytes and Macrophages in the Perivascular Adipose Tissue Are Associated With Coronary Atherosclerosis: An Autopsy Study. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 8, n. 24, DEC 17 2019. (13/00335-2, 13/12290-3)

YAHAGI-ESTEVAM, MARISTELLA; FARIAS-ITAO, DANIELA SOUZA; PARAIZO LEIT, RENATA ELAINE; RODRIGUEZ, ROBERTA DIEHL; PASQUALUCCI, CARLOS AUGUSTO; NITRINI, RICARDO; JACOB-FILHO, WILSON; POWER, MELINDA C.; SUEMOTO, CLAUDIA KIMIE. The Potential Role of Selection Bias in the Association Between Coronary Atherosclerosis and Cognitive Impairment. JOURNAL OF ALZHEIMER'S DISEASE, v. 93, n. 4, p. 10-pg., 2023-01-01. (17/11313-0, 13/12290-3, 17/24066-1, 13/00335-2)

FARIAS-ITAO, DANIELA SOUZA; PASQUALUCCI, CARLOS AUGUSTO; DE ANDRADE, RENATO ARAUJO; FERRAZ DA SILVA, LUIZ FERNANDO; YAHAGI-ESTEVAM, MARISTELLA; GELAS LAGE, SILVIA HELENA; PARAIZO LEITE, RENATA ELAINE; CAMPO, ALEXANDRE BRINCALEPE; SUEMOTO, CLAUDIA KIMIE. Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis. JOURNAL OF THE AMERICAN HEART ASSOCIATION, v. 11, n. 6, p. 30-pg., 2022-03-15. (13/12290-3, 17/11313-0, 13/00335-2, 17/24066-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ITAO, Daniela Souza Farias. Association between inflammation in perivascular epicardial adipose tissue and coronary artery disease: a clinical pathological study. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.