Analysis of intestinal microbiota in adults with different dietary patterns and possible associations with the inflammatory status, insulin sensitivity and body adiposity

• Grant number: 12/12004-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2013
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Sandra Roberta Gouvea Ferreira Vivolo
• Grantee: Ana Carolina Franco de Moraes
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 14/27221-0 - Gut microbiota of individuals with diverse dietary patterns and metabolic profile: combining the Brazilian and American research experiences, BE.EP.DR

Abstract

The intestinal microbiota is acquired in the postnatal period, consisting of a wide variety of bacteria that plays different functions in the human host, including nutrient absorption, protection against pathogens and modulation of the immune system. The intestinal bacterial content is not fully known, but is known to be influenced by internal and mainly by external factors that modulate its composition and function. Therefore, the evaluation of the microbiota may allow the use of different strategies in order to manipulate the bacterial population and promote health. Recent studies indicate that the intestinal microbiota differs in lean and obese individuals, and in those who have different feeding habits. Thus, in this cross-sectional study we aim to analyze possible differences between the microbiota of groups of eutrophic and overweight individuals showing distinct eating habits (vegan, lacto-ovo-vegetarians and omnivores) and to assess associations with inflammatory (CRP, IL-2, IL-4, IL-6, IL-8, IL-10, IL-1beta, GM-CSF, IFN-gamma and TNF-alfa) and metabolic (lipid profile, blood glucose and insulin) parameters. The evaluation of the molecular profile of the microbiota will be performed by fecal sample, using the technique of genetic sequence of 16S rRNA.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORAES, Ana Carolina Franco de. Gut microbiota analysis of adults with distinct dietary habits and associations with inflammation and insulin resistance. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.