Contractility changes in isolated cardiomyocytes following pediatric VAD support

• Grant number: 13/24543-3
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: January 01, 2014
• End date: December 31, 2017
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Idágene Aparecida Cestari
• Grantee: Gustavo Shimabukuro Marchini
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 12/50283-6 - Circulatory support in pediatric patients: ventricular assist device and extracorporeal membrane oxygenation, AP.TEM

Abstract

Heart failure is a major cause of mortality and morbidity in many countries. Despite the increasing evolution in drug therapy capable of modifying its natural evolution, the time course of the disease is inevitable. The definitive treatment still remains heart transplantation, which is, however, limited by the shortage of donors. Ventricular Assist Devices (VAD) can be used in this scenario as a bridge to heart transplantation, providing circulatory support while the patient waits for transplantation. Recent studies show that, besides hemodynamic stabilization, the use of VAD can result in improved cardiac contractility, which may lead to a recovery of the capacity of the heart to pump blood. This recovery depends on processes that occur at the cellular level and modify the myocyte contractility. The force and velocity of contraction of isolated cardiac myocytes before and after implantation of the VAD Incor in sheeps will be studied in this work. The methodology will also be applied in mapping the contractile function of cardiac myocytes from pediatric patients undergoing heart surgery. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARCHINI, GUSTAVO S.; TAMASHIRO, DANIEL S. U.; OYAMA, HELENA T.; CORTELLA, LUCAS; CESTARI, ISMAR N.; CESTARI, IDAGENE A.; IEEE. Experimental Method for Recording Epicardium Potentials and Cardiac Myocyte Shortening. 2021 COMPUTING IN CARDIOLOGY (CINC), v. 44, p. 4-pg., 2017-01-01. (13/24543-3)

MARCHINI, GUSTAVO S.; CESTARI, ISMAR N.; SALEMI, VERA M. C.; IRIGOYEN, MARIA CLAUDIA; ARNOLD, ALEXANDRE; KAKOI, ADELIA; ROCON, CAMILA; AIELLO, VERA D.; CESTARI, IDAGENE A.. Early changes in myocyte contractility and cardiac function in streptozotocin-induced type 1 diabetes in rats. PLoS One, v. 15, n. 8, AUG 21 2020. (12/50283-6, 13/24543-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MARCHINI, Gustavo Shimabukuro. Changes in cardiac contrability in an animal model of diabetes mellitus.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Escola Politécnica (EP/BC) São Paulo.