Centrifugal pump for temporary pediatric circulatory support

• Grant number: 17/25233-9
• Support type: Research Grants - Innovative Research in Small Business - PIPE
• Duration: October 01, 2018 - June 30, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Cooperation agreement: Secretary of State Government, State of São Paulo
• Principal Investigator: Mariana Maria Aparecida Pinto Hernandes
• Grantee: Mariana Maria Aparecida Pinto Hernandes
• Company: Mariana Maria Aparecida Pinto Hernandes
• City: São Paulo
• Assoc. researchers: Eduardo Guy Perpétuo Bock ; Tarcísio Fernandes Leão
• Associated scholarship(s): 18/24367-4 - Pediatric temporary circulatory support centrifugal pump, BP.PIPE

Abstract

Cardiovascular diseases are the main threat to health in contemporary Western society. This is shown in alarming numbers of morbidity, mortality and lethality when associated with other diseases. However, its incidence is not exclusively related to the modern lifestyle, sedentary lifestyle, stress, smoking and inappropriate food; cardiovascular diseases can be congenital and reach newborns, children and adolescents. Among the various stages of evolution of cardiovascular diseases, Heart Failure is a clinical syndrome associated with advanced impairment of hemodynamic functions. Under these conditions, the heart becomes unable to maintain these functions at physiological levels and requires mechanical circulatory support to maintain patients' lives. Ventricular Assist Devices (VADs) are blood pumps that enable patients to be treated (bridge to treatment) or maintain their clinical stability while waiting for a donor (transplant bridge). In this proposal, the Technical and Scientific Feasibility Analysis of a small paracorporeous centrifugal Ventricular Assist Device will be performed to be used in children with severe heart failure, as short and medium term circulatory support. The geometric characteristics of this pump will be determined by computational numerical simulations of flow analysis inside the centrifugal rotor. Physical prototypes will be built to study the manufacturing and assembly processes of DAV. Hydrodynamic performance tests and bench durability will be used for the validation of design and simulations. Blood tests will be performed to evaluate the hemolysis within the VAD, confirming its Technical-Scientific Viability. During the second phase, in the Development of the Research Proposal, the company will be constituted and will seek external financial support for the product design, supply chain, production system and its commercialization. At this stage, "in vivo" animal tests and clinical evaluation will be performed on patients. Being a product without competition in the national market, this proposal focuses on the quality and reliability from the first designs to ensure the competitiveness with its imported analogues.Acceptance by the medical community depends on these results. Given the close relationship with the academic environment of the medical and engineering areas, the company that will be created with this proposal will have the potential to be a nucleus of innovation and technological development in the area of cardiology in the state of São Paulo. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA, ROGERIO LIMA; CHABU, IVAN EDUARDO; DA SILVA, EVANDRO DRIGO; PAZIN DE ANDRADE, ARON JOSE; LEAO, TARCISIO FERNANDES; PERPETUO BOCK, EDUARDO GUY. A strategy for designing of customized electromechanical actuators of blood pumps. ARTIFICIAL ORGANS, SEP 2019. Web of Science Citations: 0.