Development of a mock circulatory system for the evaluation of pediatric ventricular assist devices

• Grant number: 14/00695-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): March 01, 2014
• Effective date (End): November 30, 2017
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Idágene Aparecida Cestari
• Grantee: Daniel Seidenberger Torres
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 12/50283-6 - Circulatory support in pediatric patients: ventricular assist device and extracorporeal membrane oxygenation, AP.TEM

Abstract

Diseases of the circulatory system are among the major causes of death in the population, and often the only treatment is heart transplantation. Ventricular Assist Devices (VADs) are used to provide circulatory support and hemodynamic stabilization in patients waiting for a heart transplant. The use of VADs is well consolidated in the United States and European countries in adult patients. In Brazil, due to the high costs of imported devices, clinical use of VADs is very limited especially for pediatric patients. A paracorporeal pulsatile device to be used as a bridge to heart transplantation in pediatric patients is being developed. A critical stage in developing mechanical support devices, especially VADs, comprises the evaluation of its performance in vitro, under simulated conditions of heart failure. In this project a mock circulatory system will be designed and developed considering the main parameters that characterize the systemic and pulmonary circulation of a pediatric patient. These parameters include vascular resistances and compliances (Windkessel model) in order to obtain flows and pressures data in both circulations under normal and heart failure conditions. The performance of the pediatric VAD InCor will be assessed using the mock circulatory system developed and the hemodynamic index of energy generated by this device will be compared to the energy generated by a continuous flow VAD. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TORRES, DANIEL S.; MAZZETTO, MARCELO; CESTARI, IDAGENE A.. A novel automated simulator of pediatric systemic circulation: Design and applications. Biomedical Signal Processing and Control, v. 70, SEP 2021. (14/00695-1, 12/50283-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TORRES, Daniel Seidenberger. InCor pediatric simulator: development of a pediatric mock circulation loop with an automated adjustment of pressures.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Escola Politécnica (EP/BC) São Paulo.