Is the frequency of periodontal pathogens dependent on some specific serotype of Aggregatibacter actinomycetemcomitans?

• Grant number: 13/24369-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2014
• End date: December 31, 2014
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: José Roberto Cortelli
• Grantee: Taís Browne de Miranda
• Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade de Taubaté (UNITAU). Taubaté , SP, Brazil

Abstract

A. actinomycetemcomitans is a gram-negative, facultative anaerobic coccobacillus bacterium that colonizes the human oral cavity. Regarding the bacterial consortium found into biofilms, previous studies have suggested that the occurrence of particular serotypes of A. actinomycetemcomitans may be related to other oral microorganisms. Interestingly, the relations among these bacterial species seem to be under influence of geographic and ethnical aspects. Objective: This aim of de presente study will be evaluate the frequency of A. actinomycetemcomitans serotype-specific antigens and its association with P. gingivalis, P. intermedia, T. forsythia and C. rectus in Brazilian subjects. Method: A total of 250 individuals A. actinomycetemcomitans positive for serotypes A, B, C and E will be allocated to this survey. Subsequently, in this same group of positive subjects, the presence of P. gingivalis, P. intermedia, T. forsythia and C. rectus from periodontal pockets will also evaluated by PCR.