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Mansonella ozzardi: a neglected filaria that may modulate the immune response to co-occurring infections

Grant number: 13/26928-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2014
Effective date (End): September 30, 2017
Field of knowledge:Biological Sciences - Parasitology - Helminthology of Parasites
Principal researcher:Marcelo Urbano Ferreira
Grantee:Nathália Ferreira Lima
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):16/06970-0 - Mansonella ozzardi: the neglected New World filarial nematode that can modulate the immune response against concomitant infections, BE.EP.DR

Abstract

Human infections with the filarial parasite Mansonella ozzardi are common in areas of tropical and subtropical Central and South America and often coexist with other endemic tropical diseases, such as malaria. In the Amazonian Basin of Brazil, infections are typically asymptomatic; most of them will remain undiagnosed. These chronic, untreated filarial infections are potentially associated with a regulatory immune environment, dominated by IL-10-producing T-cells, which mediates the suppression of T-cell proliferation in response to filarial and non-related antigens. However, the potential impact of M. ozzardi infections on immune responses to other pathogens, such as Toxoplasma gondii and Plasmodium vivax, remains unknown. Here we aim to investigate whether human M. ozzardi infections induce the expansion of CD4+ T-lymphocyte populations that express molecules with immunoregulatory potential and whether these cell populations are able to inhibit T-cell proliferative responses ex-vivo to unrelated antigens and mitogens. We will also examine plasma levels of several inflammatory and regulatory cytokines and investigate the putative cellular sources of the major immunoregulatory cytokine IL-10 during M. ozzardi infections in naturally exposed subjects living in an endemic area of Amazonas State, Brazil.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, NATHALIA F.; GONCALVES-LOPES, RAQUEL M.; KRUIZE, YVONNE C. M.; YAZDANBAKHSH, MARIA; FERREIRA, MARCELO U. CD39 and immune regulation in a chronic helminth infection: The puzzling case of Mansonella ozzardi. PLoS Neglected Tropical Diseases, v. 12, n. 3 MAR 2018. Web of Science Citations: 2.
DE OLIVEIRA, THAIS C.; RODRIGUES, PRISCILA T.; MENEZES, MARIA JOSE; GONCALVES-LOPES, RAQUEL M.; BASTOS, MELISSA S.; LIMA, NATHALIA F.; BARBOSA, SUSANA; GERBER, ALEXANDRA L.; DE MORAIS, GUILHERME LOSS; BERNA, LUISA; PHELAN, JODY; ROBELLO, CARLOS; DE VASCONCELOS, ANA TEREZA R.; ALVES, JOAO MARCELO P.; FERREIRA, MARCELO U. Genome-wide diversity and differentiation in New World populations of the human malaria parasite Plasmodium vivax. PLoS Neglected Tropical Diseases, v. 11, n. 7 JUL 2017. Web of Science Citations: 8.
FONTOURA, PABLO S.; FINCO, BRUNA F.; LIMA, NATHALIA F.; DE CARVALHO, JR., JAQUES F.; VINETZ, JOSEPH M.; CASTRO, MARCIA C.; FERREIRA, MARCELO U. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLoS Neglected Tropical Diseases, v. 10, n. 12 DEC 2016. Web of Science Citations: 3.
LIMA, NATHALIA F.; AYBAR, CECILIA A. VEGGIANI; JURI, MARIA J. DANTUR; FERREIRA, MARCELO U. Mansonella ozzardi: a neglected New World filarial nematode. PATHOGENS AND GLOBAL HEALTH, v. 110, n. 3, p. 97-107, 2016. Web of Science Citations: 6.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.