Effects of ethanol consumption and resistense exercise training on biochemical, hormonal and immunohistochemical parameters of the dorsolateral prostate of rats UChB

• Grant number: 13/25927-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2014
• End date: May 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Giovana Rampazzo Teixeira
• Grantee: Verônica Alves de Menezes
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Alcohol is one of the few psychotropic drugs that have admitted their consumption and encouraged by society. In Brazil, the figure alcoholism as one of the most serious public health problems arising from psíquo - somatic complications and the impact on the social environment. High intake of alcohol is associated with the incidence of prostate cancer and can cause further tissue lipogenesis. Experimental studies in animals and humans suggest epidemiological correlation between physical exercise and reduction in cancer development. Prostate cancer shows alteration in the metabolism of lipids and hormones. One way to mitigate the effects of alcohol in the prostate is physical exercise. Studies say that exercise alters cellular metabolism, in prostate also influencing metabolism. Based on these assumptions the objective of this study is to investigate the influence of alcoholism and physical resistance training in prostate UChB mice. Experimental model of alcoholism (lineage UChB mice) with resistance training in liquid medium will be - used. Prostatic morphology, immunohistochemical of CD36, GR and AR (androgen receptor) proteins, biochemical parameters (glucose, total protein, total cholesterol, triglycerides, HDL, LDL, VLDL) and hormonal (glucocorticoids, IGF, Testosterone will be analyzed, corticosterone and estrogen) (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEIXEIRA, GIOVANA RAMPAZZO; ALMEIDA CHUFFA, LUIZ GUSTAVO; MENDES, LEONARDO OLIVEIRA; CRUZ VERAS, ALLICE SANTOS; MCCABE, JAMES; FAVARO, WAGNER JOSE; FELIPE PINHEIRO, PATRICIA FERNANDA; ARRUDA AMORIM, JOAO PAULO; MARTINS, OTAVIO AUGUSTO; MELLO-JUNIOR, WILSON; et al. Strength training protects against prostate injury in alcoholic rats. Journal of Cellular Physiology, v. 236, n. 5, DEC 2020. (13/25927-0, 08/00479-6)

TEIXEIRA, GIOVANA RAMPAZZO; MENDES, LEONARDO OLIVEIRA; VERAS, ALLICE SANTOS CRUZ; THORPE, HAYLEY HOPE ALLYSSA; FAVARO, WAGNER JOSE; DE ALMEIDA CHUFFA, LUIZ GUSTAVO; PINHEIRO, PATRICIA FERNANDA FELIPE; MARTINEZ, FRANCISCO EDUARDO. Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate. LIPIDS IN HEALTH AND DISEASE, v. 19, n. 1, JAN 29 2020. (13/25927-0, 08/00479-6)