Evaluation of the protective effect of mesenchymal stem cells-derived microvesicles in in vivo and in vitro models of chronic kidney injury

• Grant number: 14/02912-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2014
• Effective date (End): December 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Tamiris Borges da Silva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches, AP.TEM

Abstract

Chronic kidney disease has a great impact on clinical practice, having as major options of treatment dialysis and kidney transplantation. However, due to the unbalance between the number of donors and patients at end-stage disease, besides clinical complications caused by dialysis, the scientific community tries to find new therapeutic alternatives, stronger and more effective. In this context, stem cell-based therapy has been considered an innovative strategy for the contention of chronic kidney injuries progression, and the use of mesenchymal stem cells (MSCs) has showed efficient fibrosis reduction and kidney function amelioration in experimental models. Recently, researchers demonstrated that MSCs-derived microvesicles play an important role in information transfer and cell-cell intercommunication, being as effective as MSCs in kidney repair. In this sense, this study aims to assess the protective properties of MSCs-derived microvesicles using in vivo and in vitro models of chronic kidney injury. We intend, at the end of this work, to elucidate some of the mechanisms behind the repairing activity of microvesicles, as much as access its applicability and efficacy in the experimental chronic kidney disease treatment.