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Nanostructured films of (lactated-TMC)/(CS) obtained with distinct LbL deposition methods

Grant number: 14/03511-9
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Osvaldo Novais de Oliveira Junior
Grantee:Heveline Dal Magro Follmann
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):15/06671-0 - Design and synthesis of hybrid mesoporous materials as "smart" system for anticancer drug delivery, BE.EP.PD


This research project is aimed at fabricating layer-by-layer (LbL) films made with lactated-TMC [copolymer of poly(lactic acid) and N,N,N-trimethyl chitosan] and chondroitin sulfate (CS), for which different deposition methods will be used (dipping, spraying and spin-coating). Synergy will be sought on the properties of TMC, a cationic derivative obtained by quaternization of amino groups of chitosan (CHI), which is soluble in water and displays bactericidal effect, and of poly(lactic acid), a biodegradable polymer that is highly hydrolysable in the human body and used in the medical devices. The polyanion chondroitin sulfate (CS), a natural polysaccharide with excellent pharmaceutical properties, will be used for complexing to lactated-TMC. These (lactated-TMC)/(SC) LbL films may act as coatings for devices. The films will be tested for their antibacterial properties and cell proliferation using VERO and Caco-2 cells. The interactions between (lactated-TMC)/(CS) films with vitamin B12 will be studied in order to incorporate the latter vitamin in the films for controlled release. It will therefore be possible to assess the possible use of (lactated-TMC)/(CS) LbL films in coating biomedical devices.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FOLLMANN, HEVELINE D. M.; NAVES, ALLINY F.; ARAUJO, RAFAEL A.; DUBOVOY, VIKTOR; HUANG, XIAOXI; ASEFA, TEWODROS; SILVA, RAFAEL; OLIVEIRA, JR., OSVALDO N.. Hybrid Materials and Nanocomposites as Multifunctional Biomaterials. CURRENT PHARMACEUTICAL DESIGN, v. 23, n. 26, p. 3794-3813, . (13/14262-7, 15/06671-0, 14/03511-9)
FOLLMANN, HEVELINE D. M.; MARTINS, ALESSANDRO F.; NOBRE, THATYANE M.; BRESOLIN, JOANA D.; CELLET, THELMA S. P.; VALDERRAMA, PATRICIA; CORREA, DANIEL S.; MUNIZ, EDVANI C.; OLIVEIRA, JR., OSVALDO N.. Extent of shielding by counterions determines the bactericidal activity of N,N,N-trimethyl chitosan salts. Carbohydrate Polymers, v. 137, p. 418-425, . (14/03511-9)
FOLLMANN, HEVELINE D. M.; OLIVEIRA JR, OSVALDO N.; MARTINS, ALESSANDRO C.; LAZARIN-BIDOIA, DANIELLE; NAKAMURA, V, CELSO; RUBIRA, ADLEY F.; SILVA, RAFAEL; ASEFA, TEWODROS. Nanofibrous silica microparticles/polymer hybrid aerogels for sustained delivery of poorly water-soluble camptothecin. Journal of Colloid and Interface Science, v. 567, p. 92-102, . (14/03511-9)
FOLLMANN, HEVELINE D. M.; OLIVEIRA, JR., OSVALDO N.; LAZARIN-BIDOIA, DANIELLE; NAKAMURA, CELSO V.; HUANG, XIAOXI; ASEFA, TEWODROS; SILVA, RAFAEL. Multifunctional hybrid aerogels: hyperbranched polymer-trapped mesoporous silica nanoparticles for sustained and prolonged drug release. NANOSCALE, v. 10, n. 4, p. 1704-1715, . (13/14262-7, 15/06671-0, 14/03511-9)

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