Bisphosphonate-related osteonecrosis of the jaw - study of imaginological aspects

• Grant number: 14/13055-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2014
• End date: August 31, 2015
• Field of knowledge: Health Sciences - Dentistry - Dental Radiology
• Principal Investigator: Camila Lopes Cardoso
• Grantee: Carolina Arrabal Barros
• Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil

Abstract

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an oral complication widely discussed in recent scientific literature. The immunological features of BRONJ have been weakly cited in the literature, and it is very important because in some cases, BRONJ can be asymptomatic, even without clinical signs of bone exposure, so the immunologic exam is considered the only diagnostic tool in many cases. Like other bone pathologies, BRONJ must have well-defined aspects for the final diagnosis and the early detection of changes may to establish of a prevention plan. The objective of this study is to evaluate the imaging aspects of the jaws with BRONJ, retrospectively and then correlating the extent of your involvement with variables as: age and gender, type of systemic disease, type, time and mode of administration of the bisphosphonate, clinical staging, and treatment outcome. Herein, the methodology will be based on the Treister et al, (2009) study using panoramic radiographs and/or computed tomography of patients with BRONJ. In this study, we hypothesized that there is an important correlation between imaging features with systemic clinical features and prognosis. The scientific contribution will add to the literature, a detailed evaluation and important conclusions about the prevention and prognosis of BRONJ.