Influence of peptidyl deiminase 4 and anti citrullinated antibody on mortality in patients with septic shock

• Grant number: 14/07988-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2014
• End date: August 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcos Ferreira Minicucci
• Grantee: Eloá Siqueira Magalhães
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Despite the advances in the knowledge of septic shock in the last decade, it is still the most important cause of mortality in intensive care units. The mortality rate of septic shock in the USA is 20 to 80%. During sepsis, there is an elevated production of cytokines and the development of exacerbated inflammatory processes. Recently, some studies showed the association between the inflammatory process and the process known as citrullination. Protein citrullination is the posttranslational modification of peptidyl arginine into peptidyl citrulline catalyzed by peptidyl arginine deiminase enzymes (PAD). The PAD4-mediated citrullination of histones may participate in altered gene regulation and in neutrophil extracellular traps (NETs) formation. NETs are an important innate immune mechanism to fight pathogenic bacteria and fungi. In addition, citrullination can stimulate the immunological system to produce anti-citrullinated antibodies (anti-CCP). These autoantibodies formations could be mediated by inflammation. Despite the increased inflammatory process that occurs in sepsis, there is no study that evaluates PAD4 concentration and the presence of anti-CCP in patients with septic shock. Thus the objective of this study is to evaluate the influence of serum PAD4 concentration and the presence of anti-CCP on ICU and hospital mortality of patients with septic shock. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; MAGALHAES, ELOA SIQUEIRA; WATANABE ISHIKAWA, LARISSA LUMI; SIQUEIRA BRUDER, RITA DE CASSIA; DA SILVA, EVELYN APARECIDA; GONCALVES, RENAN BRAGA; TANNI, SUZANA ERICO; et al. Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 22, n. 10, p. 4732-4737, OCT 2018. (14/17262-0, 14/07988-4)

NARA ALINE COSTA; BERTHA FURLAN POLEGATO; AMANDA GOMES PEREIRA; SÉRGIO ALBERTO RUPP DE PAIVA; ANA LÚCIA GUT; ANDRÉ LUÍS BALBI; DANIELA PONCE; LEONARDO ANTONIO MAMEDE ZORNOFF; PAULA SCHMIDT AZEVEDO; MARCOS FERREIRA MINICUCCI. Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury. Revista da Associação Médica Brasileira, v. 66, n. 11, p. 1515-1520, 2020-12-02. (14/17262-0, 14/07988-4)

COSTA, NARA ALINE; CUNHA, NATALIA BARALDI; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; MAMEDE ZORNOFF, LEONARDO ANTONIO; RUPP DE PAIVA, SERGIO ALBERTO; REIS, BRUNA ZAVARIZE; HENRIQUE FERNANDES, ANA ANGELICA; ROGERO, MARCELO MACEDO; et al. Erythrocyte SOD1 activity, but not SOD1 polymorphisms, is associated with ICU mortality in patients with septic shock. Free Radical Biology and Medicine, v. 124, p. 199-204, AUG 20 2018. (14/17262-0, 14/07988-4)

COSTA, NARA ALINE; GUT, ANA LUCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; MAGALHAES, ELOA SIQUEIRA; WATANABE ISHIKAWA, LARISSA LUMI; SIQUEIRA BRUDER, RITA DE CASSIA; DA SILVA, EVELYN APARECIDA; GONCALVES, RENAN BRAGA; TANNI, SUZANA ERICO; et al. Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 22, n. 10, p. 6-pg., 2018-10-01. (14/17262-0, 14/07988-4)