Synthesis of nitrones with pharmacological potential

• Grant number: 14/15534-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2014
• End date: August 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Artur Franz Keppler
• Grantee: Giovanna Biazolla
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 12/07717-5 - Nitrones and hydroxylamines with pharmacological properties: synthesis, exploration of antioxidant activity and cellular studies, AP.JP

Abstract

It is intended in this project synthesize unprecedented molecules containing the nitrone functional group, a group that has a great ability to trap radical species. After the synthetic step, the molecules will be subjected to in vitro tests for determine their antioxidant activity. As the effect of physiological and pharmacological compounds containing nitrones is not yet fully established, the molecules proposed in this project will be compared with nitrones and antioxidants of reference in order to understand its structure/ antioxidant activity.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATIAS, A. C.; BIAZOLLA, G.; CERCHIARO, G.; KEPPLER, A. F.. alpha-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus. Bioorganic & Medicinal Chemistry, v. 24, n. 2, p. 232-239, JAN 15 2016. (12/01397-9, 12/07717-5, 14/15534-3)