Optimization of antioxidant properties of nitrone containing compounds with pharmacological properties

• Grant number: 15/20007-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Artur Franz Keppler
• Grantee: Giovanna Biazolla
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 12/07717-5 - Nitrones and hydroxylamines with pharmacological properties: synthesis, exploration of antioxidant activity and cellular studies, AP.JP

Abstract

We intend to use structure guided modification to synthesize novel molecules containing the nitrone functional group, a group that has capacity to trap radical species. Based on data obtained experimentally and in the literature, it is proposed to synthesize the 5th. Generation of antioxidant compounds of our laboratory. After the synthesis and characterization , the novel molecules will be subjected to a chemical system which generates radical species to evaluate the antioxidant potential of the nitrone compounds. As the physiological and pharmacological effects of nitrones compounds are not yet fully established, studies comparing the new nitrones with nitrones and antioxidants reference will be performed, in order to understand the structure/antioxidant activity of the nitrone functional group.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MAMUD, JULIA F.; BIAZOLLA, GIOVANNA; MARQUES, CAROLINE S.; CERCHIARO, GISELLE; DE QUEIROZ, THIAGO B.; KEPPLER, ARTUR F.; POLO, ANDRE S.. Z to E light-activated isomerization of alpha-pyridyl-N-arylnitrone ligands sensitized by rhenium(I) polypyridyl complexes. Inorganica Chimica Acta, v. 514, JAN 1 2021. (16/21993-6, 18/14152-0, 12/07717-5, 15/20007-5, 17/07289-7)