Study of anti-Mullerian hormone in mares: relationship with age and expression of ovarian receptors

• Grant number: 14/13191-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): October 01, 2014
• Effective date (End): November 30, 2016
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Reproduction
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Marco Antonio Alvarenga
• Grantee: Renata Cristina Uliani
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated scholarship(s): 15/01113-9 - Study of anti-Mullerian hormone in mares: relationship with age and expression of ovarian receptors, BE.EP.DR

Abstract

It is well known that increasing age produces a decline in female reproductive function by reducing the pool of ovarian follicles and decline in oocyte quality. The assessment of expected reproductive life and precise measurement of ovarian reserve have been sought for some time. Due to the difficulty in accessing the pool of oocytes / follicles remaining in the ovaries, various hormonal markers have been proposed to predict ovarian reserve, such as hormones FSH, LH, progesterone, estrogen and inhibin, but none of them was able to produce reliable information about the existing pool of follicles at the ovaries. It is known that serum anti-Müllerian Hormone (AMH) decline with age and has heavily relationship with the number of follicles present in the ovaries. Today, in human medicine, it is recognized that measurement of serum AMH is a more accurate measure of ovarian reserve and has been used to predict fertility and success in assisted reproduction programs. Just as in humans, in the equine specie are several hormonal, follicular, ovarian and uterine factors which may cause reduced fertility and cyclicity in older mares, causing great economic damage. Many of these factors are still unknown, and among these, disorders of ovarian origin stand out. Thus, the objective of this study is to assess ovarian physiological factors that can affect the fertility of older mares. For this, experiments will be performed to study the relationship between AMH serum levels and age, the effect of ovariectomy on serum AMH levels and the expression of the hormone and its receptors in follicles of young and old mares. The potential and increasing use of AMH is clear, and for that future studies can be conducted to evaluate the reproductive life expectancy of mares, becomes necessary a standard reference for future comparisons, aiming to make possible its adoption in clinic practice. Apparently there is no doubt that research with AMH will intensify in the coming years. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ULIANI, RENATA C.; CONLEY, ALAN J.; CORBIN, C. JO; FRISO, AIME M.; MACIEL, LUCIANA F. S.; ALVARENGA, MARCO A.. Anti-Mullerian hormone and ovarian aging in mares. Journal of Endocrinology, v. 240, n. 2, p. 147-156, FEB 2019. (15/01113-9, 14/13777-6, 14/13191-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ULIANI, Renata Cristina. Effect of ovariectomy on age and serum concentrations of Anti-Müllerian Hormone in mares. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu Botucatu.