Mechanistic studies of the 1,3-dipolar cycloaddition (3 +2) reaction between azides and alkylidene-malononitriles: a theoretical investigation

• Grant number: 14/15839-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2014
• End date: July 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Marco Antonio Barbosa Ferreira
• Grantee: Túlio Jardini Aímola
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

We aim in this work the mechanistic study using theoretical calculations of the cycloaddition reaction (3 +2) 1,3-dipolar cycloaddition between organic azides and alkylidene-malononitriles. Our work will focus on the investigation of the transition states involved in the stages of cycloaddition and elimination, seeking to find the determining step in this catalytic cycle, understanding the different reactivity of organic azides with different steric and electronic natures. We also intend to investigate the factors that govern its regioselectivity.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHIAVEGATTI NETO, ATTILIO; SOARES, KELLY CINTRA; SANTOS, MAIARA DA SILVA; AIMOLA, TULIO JARDINI; FERREIRA, ANTONIO GILBERTO; JARDIM, GUILHERME A. M.; TORMENA, CLAUDIO FRANCISCO; PAIXAO, MARCIO WEBER; BARBOSA FERREIRA, MARCO ANTONIO. Mechanistic investigation of enolate/stabilized vinylogous carbanion-mediated organocatalytic azide (3+2) cycloaddition reactions for the synthesis of 1,2,3-triazoles. ORGANIC & BIOMOLECULAR CHEMISTRY, v. N/A, p. 8-pg., 2022-03-30. (14/15839-9, 18/01211-9, 20/10246-0, 14/50249-8, 20/01255-6, 16/24726-9, 20/13563-7)