Automated quantification of transverse relaxation time: identification of iron deposits in the brain

• Grant number: 14/19786-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2015
• End date: October 31, 2017
• Field of knowledge: Health Sciences - Medicine
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Marcondes Cavalcante Franca Junior
• Grantee: Thiago Junqueira Ribeiro de Rezende
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 15/09793-9 - Multimodal Atlas-based Analyses to Characterize Structural Damage in Friedreich's Ataxia., BE.EP.DR

Abstract

Brain iron accumulation plays a key role in several neurodegenerative disorders, such as Parkinson's disease, Multiple Sclerosis and Friedreich ataxia. In this scenario, methods that enable in vivo identification and quantification of such deposits are extremely helpful in neurological practice. There are different MRI-based strategies to estimate iron deposition. T2*/T2 relaxometry is the most widely used technique and presents significant correlation with histological measurement of iron. However, a major limitation of relaxometry is that is not automatized and ROI-based.The main objective of this study is to develop a semi-automatic method to quantify the transverse relaxation times in a voxelwise approach. Afterwards, we will perform a clinical application of this method in patients with Friedreich ataxia. Our ultimate objective will be the search for new biomarkers to help both in the clinical follow-up and in the comprehension of neurodegenerative mechanisms rated to Friedreich ataxia. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS JUNIOR, CARLOS ROBERTO; DE BORBA, FABRICIO CASTRO; MURO MARTINEZ, ALBERTO ROLIM; RIBEIRO DE REZENDE, THIAGO JUNQUEIRA; CENDES, ISCIA LOPES; PEDROSO, JOSE LUIZ; POVOAS BARSOTTINI, ORLANDO GRAZIANI; FRANCA JUNIOR, MARCONDES CAVALCANTE. Vinte e cinco anos desde a identificação do primeiro gene das SCAs: história, aspectos clínicos e perspectivas para a SCA1. Arquivos de Neuro-Psiquiatria, v. 76, n. 8, p. 555-562, AUG 2018. (13/01766-7, 14/19786-7)

MARTINEZ, ALBERTO R. M.; CASSEB, RAPHAEL F.; MARTINS, JR., CARLOS R.; NUCCI, ANAMARLI; FRANCA, JR., MARCONDES C.. Sensory neuronopathy heralding human T cell lymphotropic virus type I myelopathy. JOURNAL OF NEUROVIROLOGY, v. 24, n. 3, p. 369-371, JUN 2018. (13/01766-7, 14/19786-7)

REZENDE, THIAGO JUNQUEIRA R.; MARTINEZ, ALBERTO ROLIM M.; FABER, INGRID; GIROTTO, KAREN; PEDROSO, JOSE LUIZ; BARSOTTINI, ORLANDO G.; LOPES-CENDES, ISCIA; CENDES, FERNANDO; FARIA, ANDREIA V.; FRANCA, MARCONDES C.. Structural signature of classical versus late-onset friedreich's ataxia by Multimodality brain MRI. Human Brain Mapping, v. 38, n. 8, p. 4157-4168, AUG 2017. (13/07559-3, 13/01766-7, 14/19786-7)

ALBERTO R. M. MARTINEZ; CARLOS ROBERTO MARTINS JR; LUCAS N. DE RESENDE; TÂNIA A. M. O. CARDOSO; FABIANO REIS; MARCONDES C. FRANÇA JR. Síndrome de Lemierre como causa de trombose venosa cerebral. Arquivos de Neuro-Psiquiatria, v. 76, n. 5, p. 358-358, 2018-05-00. (13/01766-7, 14/19786-7)

RIBEIRO REZENDE, THIAGO JUNQUEIRA; RIBEIRO DE PAIVA, JEAN LEVI; MURO MARTINEZ, ALBERTO ROLIM; LOPES-CENDES, ISCIA; PEDROSO, JOSE LUIZ; POVOAS BARSOTTINI, ORLANDO GRAZIANI; CENDES, FERNANDO; FRANCA, JR., MARCONDES C.. Structural signature of SCA3: From presymptomatic to late disease stages. ANNALS OF NEUROLOGY, v. 84, n. 3, p. 401-408, SEP 2018. (17/13102-7, 13/07559-3, 13/01766-7, 14/19786-7)

REZENDE, T. J. R.; MARTINEZ, A. R. M.; FABER, I.; GIROTTO TAKAZAKI, K. A.; MARTINS, M. P.; DE LIMA, F. D.; LOPES-CENDES, I.; CENDES, F.; FRANCA, M. C.. Developmental and neurodegenerative damage in Friedreich's ataxia. EUROPEAN JOURNAL OF NEUROLOGY, v. 26, n. 3, p. 483-489, MAR 2019. (13/26410-0, 14/19786-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

REZENDE, Thiago Junqueira Ribeiro de. Neuroimaging in Friedreich's ataxia: new approaches and clinical aplication. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.