Encapsulation and drug release of metalorganic framework based on cyclodextrin

• Grant number: 15/01199-0
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: April 09, 2015
• End date: June 08, 2015
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Leila Aparecida Chiavacci Favorin
• Grantee: Marina Paiva Abuçafy
• Supervisor: Ruxandra Gref
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: Université Paris-Sud (Paris 11), France
• Associated to the scholarship: 14/10888-1 - Development and characterization of metallo organic frameworks based on cyclodextrin, BP.MS

Abstract

This project is associated to FAPESP master fellowship process number 2014/10888-1, entitled: "Development and characterization of Metalo Organic Frameworks based on Cyclodextrin". The work will be realized under supervisor of the Prof. Dr. Ruxandra Gref (University of Paris-Sud, France). This researcher is Director at the French Centre National de la Recherche Scientifique (CNRS) and she is the coordinator of the European project "CycloN Hit" aiming to engineer novel nanocarriers based on cyclodextrin for the delivery of antimicrobial agents to fight resistance mechanism. Therefore, she was chosen as responsible for this internship due to her immense experience with incorporation of drugs in cyclodextrin based systems, drug release systems and their characterization. The time required to develop the research activities in the proposal are two months. The aim of this project is during the stage in the French laboratory to explore the study of encapsulation and drug release, such as antibiotic acid pipemidic, and analyze its performance through the characterization. The first step of the experimental work will be encapsulate the metalorganic framework by incubating with the drug aqueous solution. The encapsulation will be monitored by UV-Vis. After drug incorporation the release of the drug will be monitored through the HPLC, which will allow to quantify and to analyze kinetic release. (AU)