Determination of plasma phospholipids in neuropsychiatric disorders

• Grant number: 14/20913-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2015
• End date: August 31, 2016
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Wagner Farid Gattaz
• Grantee: Alana Caroline Costa
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Phospholipids and related molecules comprise 60% of the nonaqueous portion of the brain and an even larger proportion of dendrites and synapses; they are the major constituents of membrane of neuronal and glial cells of the synaptic vesicle membrane, nuclear endoplasmic reticulum membranes of mitochondria and Golgi complex. The phospholipids are essential for all living cells and therefore changes in metabolism might influence the organism. It is known that changes in metabolism of phospholipids are involved in several neuropsychiatric disorders including Alzheimer's disease, schizophrenia and bipolar disorder. However, these changes appear to be distinct in each neuropsychiatric disease. Determining changes in the composition of plasma phospholipids in each of these diseases, may help to elucidate the pathophysiological mechanisms, and also in the search for candidates of specific biomarkers. For this, chromatography coupled to mass spectrometry is a good method since it provides a comprehensive profile of the substances being studied. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, ALANA C.; JOAQUIM, HELENA P. G.; FORLENZA, V, ORESTES; GATTAZ, WAGNER F.; TALIB, LEDA L.. Three plasma metabolites in elderly patients differentiate mild cognitive impairment and Alzheimer's disease: a pilot study. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 270, n. 4, p. 483-488, JUN 2020. (14/50873-3, 14/20913-3)

JOAQUIM, HELENA P. G.; COSTA, ALANA CAROLINE; SERPA, MAURICIO HENRIQUES; TALIB, LEDA L.; GATTAZ, WAGNER F.. Reduced Annexin A3 in schizophrenia. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 270, n. 4, p. 489-494, JUN 2020. (14/50873-3, 14/20913-3)

JOAQUIM, HELENA P. G.; COSTA, ALANA C.; GATTAZ, WAGNER F.; TALIB, LEDA LEME. Kynurenine is correlated with IL-1 beta in plasma of schizophrenia patients. JOURNAL OF NEURAL TRANSMISSION, v. 125, n. 5, p. 5-pg., 2018-05-01. (13/10350-9, 14/50873-3, 14/20913-3)

HELENA P. G. JOAQUIM; ALANA C. COSTA; ORESTES V. FORLENZA; WAGNER F. GATTAZ; LEDA L. TALIB. Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer’s disease patients. ARCHIVES OF CLINICAL PSYCHIATRY, v. 46, n. 5, p. 120-124, 2019-11-25. (14/50873-3, 14/20913-3)

JOAQUIM, HELENA P. G.; COSTA, ALANA C.; GATTAZ, WAGNER F.; TALIB, LEDA LEME. Kynurenine is correlated with IL-1 beta in plasma of schizophrenia patients. JOURNAL OF NEURAL TRANSMISSION, v. 125, n. 5, SI, p. 869-873, MAY 2018. (14/50873-3, 14/20913-3, 13/10350-9)

COSTA, ALANA C.; JOAQUIM, HELENA P. G.; TALIB, LEDA L.; SERPA, MAURICIO H.; ZANETTI, MARCUS V.; GATTAZ, WAGNER F.. Plasma metabolites in first episode psychoses. SCHIZOPHRENIA RESEARCH, v. 206, p. 468-470, APR 2019. (14/20913-3)

COSTA, ALANA C.; JOAQUIM, HELENA P. G.; FORLENZA, ORESTES; TALIB, LEDA L.; GATTAZ, WAGNER F.. Plasma lipids metabolism in mild cognitive impairment and Alzheimer's disease. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 20, n. 3, p. 190-196, MAR 16 2019. (14/20913-3)

GONCALVES DE FREITAS PEREIRA, MARTA LUISA; DE ARRUDA CAMARGO, MARINA VON ZUBEN; RIBEIRO BELLAN, ARIELLA FORNACHARI; TAHIRA, ANA CAROLINA; DOS SANTOS, BERNARDO; DOS SANTOS, JESSICA; MACHADO-LIMA, ARIANE; NUNES, FATIMA L. S.; FORLENZA, ORESTES VICENTE. Visual Search Efficiency in Mild Cognitive Impairment and Alzheimer's Disease: An Eye Movement Study. JOURNAL OF ALZHEIMER'S DISEASE, v. 75, n. 1, p. 261-275, 2020. (13/23135-9, 17/12339-3, 14/20913-3, 15/19632-2)

JOAQUIM, HELENA P. G.; COSTA, ALANA C.; TALIB, LEDA L.; DETHLOFF, FREDERIK; SERPA, MAURICIO H.; ZANETTI, V, MARCUS; VAN DE BILT, MARTINUS; TURCK, CHRISTOPH W.. Plasma Metabolite Profiles in First Episode Psychosis: Exploring Symptoms Heterogeneity/Severity in Schizophrenia and Bipolar Disorder Cohorts. FRONTIERS IN PSYCHIATRY, v. 11, JUN 5 2020. (14/50873-3, 14/20913-3)

DE ARRUDA CAMARGO, MARINA VON ZUBEN; PAIS, MARCOS VASCONCELOS; RIBEIRO BELLAN, ARIELLA FORNACHARI; TAHIRA, ANA CAROLINA; DOS SANTOS, BERNARDO; FIDALGO GARCEZ SANT'ANA, LIVEA CARLA; RADANOVIC, MARCIA; FORLENZA, ORESTES VICENTE. Impact of Cognitive Demand on Eye Movement Pattern in Patients with Alzheimer's Disease. JOURNAL OF ALZHEIMER'S DISEASE, v. 90, n. 1, p. 11-pg., 2022-01-01. (17/12339-3, 13/23135-9, 15/19632-2, 14/20913-3)

JOAQUIM, HELENA P. G.; COSTA, ALANA C.; FORLENZA, ORESTES, V; GATTAZ, WAGNER E.; TALIB, LEDA L.. Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients. ARCHIVES OF CLINICAL PSYCHIATRY, v. 46, n. 5, p. 5-pg., 2019-09-01. (14/50873-3, 14/20913-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

COSTA, Alana Caroline. Determination of plasma phospholipids in neuropsychiatric disorders. 2017. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.