Periodontal debridement associated with two different antibiotic agents to treat generalized aggressive periodontitis: randomized clinical trial

• Grant number: 14/22078-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2015
• End date: January 31, 2017
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Mauro Pedrine Santamaria
• Grantee: Cássia Fernandes Araujo
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

Generalized aggressive periodontitis is a periodontal condition that may require the association of mechanical therapy - Scaling and Root Planning (SRP) - with the use of antimicrobial agents in order to obtain a better result in treating the disease. Several studies show the effectiveness of the use of amoxicillin (AMX) and metronidazole (MET) associated with SRP. However, the literature has already pointed that the extensive use of these antimicrobials could generate bacterial resistance. In order to evaluate new approaches, the present randomized clinical trial is aimed to assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. To this, forty (40) patients will be selected and randomly assigned into two groups: test group (n=20): periodontal debridement associated with clarithromycin (500mg - 12/12 hours) for 3 days; and control group (n=20): periodontal debridement associated with amoxicillin (500mg - 8/8 hours) and metronidazole (400mg - 8/8 hours) for 7 days . Probing depth (PD), gain in Clinical Attachment Level (CAL) and Bleeding Probing (BP) will be evaluated at baseline, 3 and 6 months post-operatively. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARAUJO, CASSIA F.; ANDERE, NAIRA M. R. B.; CASTRO DOS SANTOS, NIDIA C.; MATHIAS-SANTAMARIA, INGRID F.; REIS, AURELIO A.; DE OLIVEIRA, LUCIANE D.; JARDINI, MARIA A. N.; CASARIN, RENATO C. V.; SANTAMARIA, MAURO P.. Two different antibiotic protocols as adjuncts to one-stage full-mouth ultrasonic debridement to treat generalized aggressive periodontitis: A pilot randomized controlled clinical trial. Journal of Periodontology, v. 90, n. 12, p. 10-pg., 2019-12-01. (18/02161-5, 14/22078-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ARAUJO, Cássia Fernandes. Full-mouth ultrasonic debridement associated with two different antibiotic protocols to treat generalized aggressive periodontitis: randomized controlled clinical trial. 2017. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.