Evaluation of prognostic factors and therapeutic targets related to epithelial-mesenchymal transition and tumor microenvironment of canine mammary carcinomas

• Grant number: 15/09046-9
• Support type: Scholarships abroad - Research Internship - Doctorate
• Effective date (Start): September 08, 2015
• Effective date (End): January 31, 2016
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Renee Laufer Amorim
• Grantee: Talita Mariana Morata Raposo Ferreira
• Supervisor abroad: Karin Sorenmo
• Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Local de pesquisa : University of Pennsylvania, United States
• Associated to the scholarship: 13/03940-4 - Study on large-scale of gene expression of bitches mammary carcinomas, BP.DR

Abstract

Mammary tumors are the most prevalent tumor in female dogs as well as in women. The study of markers that can be involved in metastatic development can help a better understanding of the carcinogenic process of this tumor, besides allow to identify prognostic markers and potential therapeutic targets that can contribute in both canine and human species. Dr Karin Sorenmo is a renowned researcher with publications of high impact in the most renowned international journals mainly with mammary and prostatic cancers. Dr Susan Volk is another important researcher with a main line of research tumor microenvironment. Both Professors conduct the canine mammary tumor research project at the University of Pennsylvania. Our group has been studying mammary tumors in female dogs with important results and the collaboration of these both renowned researchers will contribute to the better understanding of the results we have obtained with large-scale gene profile studies. Besides, from these results of large-scale gene profile we will select gene expression pathways related to epithelial-mesenchymal transition (EMT) and tumor microenvironment and we will validate the results by RT-qPCR, analysis of protein expression and cellular culture to identify prognostic factors and potential therapeutic targets for canine mammary tumors. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAPOSO-FERREIRA, TALITA M. M.; BRISSON, BECKY K.; DURHAM, AMY C.; LAUFER-AMORIM, RENEE; KRISTIANSEN, VERONICA; PURE, ELLEN; VOLK, SUSAN W.; SORENMO, KARIN. Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. VETERINARY PATHOLOGY, v. 55, n. 5, p. 622-633, SEP 2018. Web of Science Citations: 5.